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SyGMa specifications


Unique identifier OMICS_15732
Name SyGMa
Alternative name Systematic Generation of potential Metabolites
Software type Package/Module
Interface Command line interface
Restrictions to use Academic or non-commercial use
Operating system Unix/Linux
Programming languages Python
License GNU General Public License version 3.0
Computer skills Advanced
Stability Stable
Maintained Yes




No version available



  • person_outline Lars Ridder

Publication for Systematic Generation of potential Metabolites

SyGMa citations


Description of the protocol for the PRACTICAL study: a randomised controlled trial of the efficacy and safety of ICS/LABA reliever therapy in asthma

PMCID: 5647477
PMID: 29071080
DOI: 10.1136/bmjresp-2017-000217

[…] therapy alone, indicating better control of airway inflammation. Based on this evidence, two double-blind regulatory RCTs of as-needed budesonide/formoterol (SYmbicort Given as needed in Mild Asthma, SYGMA) are currently underway, together with an open-label RCT of as-needed budesonide/formoterol in patients currently taking only SABA reliever therapy (Novel Symbicort Therapy As Reliever Therapy, […]


RD Metabolizer: an integrated and reaction types extensive approach to predict metabolic sites and metabolites of drug like molecules

Chem Cent J
PMCID: 5515729
PMID: 29086838
DOI: 10.1186/s13065-017-0290-4

[…] approaches. Expert systems mainly employ generic metabolic rules derived by expert to predict structures of metabolites. Typical examples of expert systems are META [–], MetabolExpert [], Meteor [], SyGMa [], TIMES []. For the fingerprint-based data mining approaches, MetaPrint2D-React [], an extension of MetaPrint2D, is a typical and representative method. It is and allows users to predict struc […]


Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing

Sci Rep
PMCID: 5468315
PMID: 28607474
DOI: 10.1038/s41598-017-03171-4

[…] ots. She has received consulting/lecture fees or served as a board member for Alertness Solution, Ceridian, Davis Joint Unified School Board, San Jose State University Foundation, Pugot Sound Pilots, Sygma and Torvec. RWP is a co-founder of and shareholder in Empatica Inc and Affectiva Inc and serves on the board of Empatica. She is inventor or co-inventor on over two dozen patents, mostly in the […]


Efficacy of budesonide/formoterol maintenance and reliever therapy compared with higher dose budesonide as step up from low dose inhaled corticosteroid treatment

PMCID: 5397768
PMID: 28427362
DOI: 10.1186/s12890-017-0401-y

[…] trials are required to confirm these findings in patients with milder asthma and lower baseline reliever use. The use of ICS/LABA as-needed in mild asthma is currently being evaluated in the ongoing SYGMA studies []. In the present analysis, the selection only of patients on Step 2 treatment at entry, and sub-division by baseline as-needed reliever use, reduced the power of the analyses, with onl […]


The SYGMA programme of phase 3 trials to evaluate the efficacy and safety of budesonide/formoterol given ‘as needed’ in mild asthma: study protocols for two randomised controlled trials

PMCID: 5223341
PMID: 28069068
DOI: 10.1186/s13063-016-1731-4

[…] The primary outcome measure in SYGMA1, well-controlled asthma weeks (as-needed budesonide/formoterol versus as-needed terbutaline (superiority) and as-needed budesonide/formoterol versus maintenance budesonide plus as-needed terbut […]


TRPA5, an Ankyrin Subfamily Insect TRP Channel, is Expressed in Antennae of Cydia pomonella (Lepidoptera: Tortricidae) in Multiple Splice Variants

PMCID: 5026476
PMID: 27638948
DOI: 10.1093/jisesa/iew072

[…] h). Amplifications were conducted according to the recommended protocols. Primers were designed by hand using existing contig data as reference. Thermodynamic features were checked by OligoEvaluator (Sygma Genosys,, and putative oligodimerization was checked by OligoAnalyzer 3.1 (Integrated DNA Technologies, Primer melting tempera […]


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SyGMa institution(s)
Molecular Design and Informatics, Organon, part of Schering-Plough Corporation, Oss, Netherlands

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