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Synthetic lethality prediction software tools | Pathway analysis

Two genes are said to be in a synthetic lethality (SL) relationship if a perturbation of either gene alone is not lethal but perturbations of both genes lead to cell death or a dramatic decrease in cell viability (Boone et al., 2007). Source text:…
SynLethDB
Dataset

SynLethDB Synthetic Lethality DataBase

A comprehensive database of synthetic lethality (SL). SL pairs were collected…

A comprehensive database of synthetic lethality (SL). SL pairs were collected from multiple sources, including biochemical assays, other related databases, computational predictions and text-mining…

Cell line…
Desktop

Cell line recognition

Cell line recognition and normalization system, supporting corpora and tagged…

Cell line recognition and normalization system, supporting corpora and tagged documents. The aim is to create corpora that is suitable for training and evaluating machine learning systems to…

SL Finder
Desktop

SL Finder

Proposes a targeted enumeration procedure for identification of synthetic…

Proposes a targeted enumeration procedure for identification of synthetic lethal (SL) genes or reactions using genome-scale metabolic models. SL Finder relies on the solution of a bilevel…

MutExSL
Desktop

MutExSL

A computational approach to infer synthetic lethality interactions directly…

A computational approach to infer synthetic lethality interactions directly from frequently altered genes in human cancers. MutExSL is based on the observation that pairs of genes that are altered in…

MetaSL
Desktop

MetaSL

An approach for predicting yeast synthetic lethality, which integrates 17…

An approach for predicting yeast synthetic lethality, which integrates 17 genomic and proteomic features and the outputs of 10 classification methods. MetaSL thus combines the strengths of existing…

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