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SZGene specifications


Unique identifier OMICS_05767
Name SZGene
Alternative name SchizophreniaGene
Restrictions to use None
Maintained Yes


  • Primates
    • Homo sapiens

Publication for SchizophreniaGene

SZGene citations


Comparative Genomic Evidence for the Involvement of Schizophrenia Risk Genes in Antipsychotic Effects

Mol Psychiatry
PMCID: 5709242
PMID: 28555076
DOI: 10.1038/mp.2017.111

[…] top 25 most studied schizophrenia candidate genes () (P=0.00018) and eight (CARTPT, CHRNA7, GABRA6, GSTT2, HTR2A, NTS, PENK, SLC6A4) are among the 864 orthologous schizophrenia candidate genes in the SzGene database() (P=0.05, ). Notably, genetic evidence for association with schizophrenia for most of these genes is currently lacking (). Many of these candidate genes were proposed based on pharmac […]


A new method for identifying causal genes of schizophrenia and anti tuberculosis drug induced hepatotoxicity

Sci Rep
PMCID: 5007646
PMID: 27580934
DOI: 10.1038/srep32571

[…] en reported to associate with both ATDH and SCZ; all other genes were reported to associate with at most either disease alone. Genes with significant effects only on SCZ, which were obtained from the SzGene database or a systemic meta-analysis of genome wide association study (GWAS) data provided by Ricopili, are listed in ; in the future, association of these genes with ATDH will require testing. […]


Evaluation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis

BMC Med Genet
PMCID: 4557634
PMID: 26208850
DOI: 10.1186/s12881-015-0197-7

[…] polymorphism (OR scz/per T-allele) was evaluated by conducting a meta-analysis of case–control studies with the random-effect model by ‘metafor’, an R package. Eligible studies were identified using SZGene [] and the PubMed search engine with the terms “Methylenetetrahydrofolate reductase” or “MTHFR” or “schizophrenia”. We also conducted an additional manual search of reference lists and review a […]


Transcriptome alterations of mitochondrial and coagulation function in schizophrenia by cortical sequencing analysis

BMC Genomics
PMCID: 4290619
PMID: 25522158
DOI: 10.1186/1471-2164-15-S9-S6

[…] neric risk prediction and RNA-Seq data analysis. Several novel candidate genes and potential pathways were associated to the susceptibility mechanism of schizophrenia. The candidate genes reported by SZGene[], Huang et al.(2013)[], Sellmann et al.(2013)[], Ayalew M et al.(2012)[], Wu et al.(2012)[] and SCZCGs were compared and revealed high inconsistency of putative genes and pathways, results are […]


Searching joint association signals in CATIE schizophrenia genome wide association studies through a refined integrative network approach

BMC Genomics
PMCID: 3481439
PMID: 23134571
DOI: 10.1186/1471-2164-13-S6-S15

[…] module gene lists, such as AKT1, DTNBP1, ESR1, FLNB, GRIN1, IL4, NOS1AP, YWHAZ, and others. When compared to the genes previously studied for associations with schizophrenia as those deposited in the SzGene database [], a total of 27 module genes were found to have positive association results (Table ). Further examination of these genes showed that only a few of them were simultaneously identifie […]


DISC1 Conditioned GWAS for Psychosis Proneness in a Large Finnish Birth Cohort

PLoS One
PMCID: 3281861
PMID: 22363459
DOI: 10.1371/journal.pone.0030643

[…] ) (for details Supplementary Information). Coding genes in these regions of interest were analyzed for prior evidence for a role in psychiatric illness using UCSC Genome Browser (NCBI Build 36.1) and SZGene . Further, a linkage disequilibrium analysis for the suggestive SNPs was performed using program Haploview . The average r2of neighboring SNPs was 0.74 suggesting that they are relatively indep […]


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SZGene institution(s)
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA

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