T-cell receptor sequence databases | Immunology system data analysis
The ability to decode antigen specificities encapsulated in the sequences of rearranged T-cell receptor (TCR) genes is critical for our understanding of the adaptive immune system and promises significant advances in the field of translational medicine. Recent developments in high-throughput sequencing methods (immune repertoire sequencing technology, or RepSeq) and single-cell RNA sequencing technology have allowed us to obtain huge numbers of TCR sequences from donor samples and link them to T-cell phenotypes.
Compiles experimental data dealing with antibody and T-cell epitopes studied in various animal species encompassing humans and non-human primates. IEDB proposes a repository allowing six types of searches, including queries by assay, host or epitope, coupled to utilities for t- or b-cell epitope prediction. Data available on this database is derived from various diseases such as allergic or infectious ones as well as from diseases associated with transplantation.
Collects and curates T-cell receptors (TCR) structural data from the protein data bank (PDB). STCRDab aims to act as a resource for the emerging field of computational TCR design. It provides a bridge to the extensive knowledge base of antibody structures in SAbDab, which can potentially be used to inform TCR-like antibody design or antibody-like TCR design.
Provides a repository of biologically diverse diseases for assisting scalable data mining of immune repertoires in both nucleotide and amino acids forms. PIRD gathers raw and processed sequences of immunoglobulins (IGs) and T-cell receptors (TCRs) of human and other vertebrate species with different phenotypes from more than 20 different databases. Some analysis sample functions are available, and analysis results can be saved and retrieved into the platform.
Deals with immunogenetics and immunoinformatics. IMGT provides a platform giving access to information related with immunoglobulins, T cell receptors, major histocompatibility complex of human and other vertebrate species, as well as with related proteins of the immune systems of several species. It includes 7 databases, more than 10 online tools and resources including veterinary pages, diaporama and scientific charts.
Provides T cell receptor (TCR) sequences associated with various pathologies and antigens. McPAS-TCR aims to assemble information on pathology-related TCR sequences by extracting information from published literature. It offers more than 5 100 sequences of TCRs related with various pathologic conditions and the antigens associated with everyone. The database is manually curated and is consultable by T cell type, tissue, epitope, source organism, major histocompatibility complex (MHC) restriction, assay type and other criteria.
Provides a bridge between immunological gene data and cancer studies. The CIG-DB is a semi-automated database that integrates the information on immunoglobulin, T-cell receptor, and epitopes reported in cancer studies. It also presents sequence analysis tools, and structural data. The CIG-DB provides two search engines: (i) sequence search and (ii) reference search, which users can select on the home page.