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Analyzes genome-wide expression patterns in one experiment at a time. T-profiler is a web application that uses the t-test to score the difference between the mean expression level of predefined groups of genes and that of all other genes on the microarray. The consensus motifs derive from three different sources: (i) motifs are extracted from the Promoter Database of Saccharomyces cerevisiae (SCPD) database, (ii) motifs are found by comparing the genome sequences of highly related yeast species, and (iii) motifs discovered from various microarray experiments using the REDUCE algorithm were added.

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T-profiler classification

  • Fungi
    • Candida albicans
    • Saccharomyces cerevisiae

T-profiler specifications

Web user interface
Input data:
A microarray data.
Computer skills:
Restrictions to use:
Input format:

T-profiler support


  • Harmen J. Bussemaker <>


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Swammerdam Institute for Life Sciences–Microbiology, University of Amsterdam, Biocentrum Amsterdam, Amsterdam, Netherlands; Department of Biological Sciences, Columbia University, New York, NY, USA; Center for Computational Biology and Bioinformatics, Columbia University, New York, NY, USA

Funding source(s)

Supported by grants from the Netherlands Foundation for Technical Research (STW) (APB.5504) and from the National Institutes of Health to (R01HG003008).

Link to literature

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