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T1Dbase specifications


Unique identifier OMICS_05765
Name T1Dbase
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Maintained No


  • Primates
    • Homo sapiens


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Publications for T1Dbase

T1Dbase citations


Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice

PMCID: 4635565
PMID: 26438525
DOI: 10.4049/jimmunol.1402654

[…] notations present in RefSeq (NCBIM37) (), CCDS (Release 7) (), UCSC (mm9, http://genome.ucsc.edu/) (), and Ensembl and Vega (both Release 67) (). All annotations described above were entered into the T1Dbase () displayed graphically using Gbrowse () and can be viewed at http://www.t1dbase.org. […]


Inflammation related genetic variants predict toxicities following definitive radiotherapy for lung cancer

Clin Pharmacol Ther
PMCID: 4206576
PMID: 25054431
DOI: 10.1038/clpt.2014.154
call_split See protocol

[…] e definitions and SNP identification were described previously(). Briefly, inflammatory-related genes were defined based on a pre-defined inflammation panel, and refined through database exploration (T1DBase [http://www.t1dbase.org]; University of Cambridge, Cambridge, UK). Tagging SNPs within a 10kb flanking region of each candidate gene region were identified using the Tagger pairwise method() w […]


Molecular pathway alterations in CD4 T cells of nonobese diabetic (NOD) mice in the preinsulitis phase of autoimmune diabetes

PMCID: 4050318
PMID: 24918037
DOI: 10.1016/j.rinim.2014.05.001

[…] o the NOD CD4 T-cell altered genes discussed above, several other altered genes also lie within Idds (). All (except Idd5.4a/5.4) have been identified as conferring resistance to diabetes (http://www.t1dbase.org). An interesting family of genes highlighted is the tripartite-motif (Trim) family. Compared to the leukocyte study, the current study expanded the list of Trim family members. These genes […]


Inflammation related Genetic Variations and Survival for Advanced Non Small Cell Lung Cancer Receiving First line Chemotherapy

Clin Pharmacol Ther
PMCID: 4141040
PMID: 24755914
DOI: 10.1038/clpt.2014.89

[…] notyping BeadChip was designed to genotype genetic variants in inflammation-related genes (study design detailed in ). Genes involved in inflammatory responses and regulation were retrieved using the T1Dbase (http://www.t1dbase.org; University of Cambridge), which focuses on diabetes-related and inflammation-related genes. Additional gene information was obtained from the WKINFLAM panel (). Taggin […]


Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity

Mamm Genome
PMCID: 3824839
PMID: 23934554
DOI: 10.1007/s00335-013-9466-y

[…] o been sequenced using next-generation sequencing technology (http://www.sanger.ac.uk/resources/mouse/genomes/). Single nucleotide polymorphisms (SNPs) from the analyzed Idd regions were entered into T1Dbase (Hulbert et al. ; Smink et al. ) and displayed graphically using Gbrowse (Stein et al. ). Variant SNPs between strains were downloaded from the Mouse Phenome Database (http://phenome.jax.org/) […]


GeneSpeed Beta Cell: An Online Genomics Data Repository and Analysis Resource Tailored for the Islet Cell Biologist

PMCID: 2532782
PMID: 18795106
DOI: 10.1155/2008/312060

[…] important pillar for array data compilation. In contrast to the more universal user-base that GEO seeks to cover, certain resources have also been made available and dedicated to the islet community. T1Dbase (http://www.t1dbase.org/) was specifically developed to catalogue information on the genetics of type-I diabetes, and contains extensive information on candidate gene regions []. It also conta […]

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T1Dbase institution(s)
Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge, UK
T1Dbase funding source(s)
Supported by The Wellcome Trust (WT), the National Institute of Diabetes and Digestive Kidney Diseases (NIDDK), the National Institute for Health Research (NIHR) and Juvenile Diabetes Research Foundation (JDRF).

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