Online

Classifies the protein fold by combing the results from two algorithms, HH-fold and support vector machines (SVM)-fold. TA-fold is an ensemble approach proposed to combine the results of these algorithms. HH-fold is a template-based fold assignment algorithm using the Hidden Markov Model (HMM)-HMM alignment program HHsearch. SVM-fold is a support vector machine-based ab-initio classification algorithm. When there are homologous templates to the query protein, HH-fold prediction is reported. Otherwise, the SVM-fold prediction is returned.

User report

0 user reviews

0 user reviews

No review has been posted.

TA-fold forum

No open topic.

TA-fold classification

TA-fold specifications

Software type:
Package
Restrictions to use:
None
Input format:
FASTA
Computer skills:
Basic
Interface:
Web user interface
Input data:
A protein sequence
Output data:
Predicted fold type
Stability:
Stable

Credits

Publications

  • (Xia et al., 2016) An ensemble approach to protein fold classification by integration of template-based assignment and support vector machine classifier. Bioinformatics.
    PMID: 28039166

Institution(s)

Department of Physics, Northeast Forestry University, Harbin, China; Center for Applied Mathematics, Tianjin University, Tianjin, China; School of Mathematical Sciences, Nankai University, Tianjin, China

Funding source(s)

The project is supported in part by National Natural Science Foundation of China (11501306, 11501407), China National 863 High-Tech Program (2015AA020101) and the Thousand Youth Talents Plan of China.

Link to literature

Related Tertiary structure prediction tools

Most Recent Tools

LiveBench
Data

LiveBench

Is a continuously running benchmark project for assessing the quality of…

Is a continuously running benchmark project for assessing the quality of protein structure prediction and secondary structure prediction methods. LiveBench focuses mainly on homology modeling and…

EVA
Data

EVA

Aims to evaluate the accuracy of automated protein structure prediction…

Aims to evaluate the accuracy of automated protein structure prediction methods. EVA is updated automatically each week, to cope with the large number of existing prediction servers and the constant…

Edlib
Desktop

Edlib

Calculates exact pairwise sequence alignment using edit distance. Edlib…

Calculates exact pairwise sequence alignment using edit distance. Edlib supports the global alignment method and the semi-global alignment method where gaps at the end of the query sequence are not…

CNS
Desktop

CNS Crystallography & NMR System

Provides a flexible multi-level hierachical approach for the most commonly used…

Provides a flexible multi-level hierachical approach for the most commonly used algorithms in macromolecular structure determination. CNS allows heavy atom searching, experimental phasing (including…

Most Popular Tools

ProteinLounge
Web

ProteinLounge

Develops many interactive web-based databases and software to help the…

Develops many interactive web-based databases and software to help the life-scientists understand the complexity of systems biology. Systems biology efforts focus on understanding cellular networks,…

16 related tools

By using OMICtools you acknowledge that you have read and accepted the terms of the end user license agreement.