TALENoffer statistics

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TALENoffer specifications

Information


Unique identifier OMICS_04713
Name TALENoffer
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Computer skills Advanced
Stability No
Maintained No

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Unique identifier OMICS_04713
Name TALENoffer
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability No
Maintained No

Publication for TALENoffer

TALENoffer in publications

 (9)
PMCID: 5622416
PMID: 28962583
DOI: 10.1186/s13287-017-0651-x

[…] l2 + r2 talen pair caused off-target editing that may cause unwanted mutations at another locus in the genome of these positive clones, we amplified the top 10 potential off-target sites (obtained by talenoffer software []) by genomic pcr and performed dna sequencing. no off-target editing events were found (additional file : table s2). we termed these heterozygous hescs with correct neomycin or e […]

PMCID: 5031972
PMID: 27654750
DOI: 10.1038/srep33675

[…] the nuclear donor cell., to assess the specificity of talen cleavage, we identified the 100 most likely off-target sites () based on the sheep reference genome using the local-mixture model method talenoffer. we performed high-coverage whole-genome resequencing of an mstn mutant genome and called confident small indels and single-nucleotide variants (snvs) (see methods). our resequencing data […]

PMCID: 5034111
PMID: 27502025
DOI: 10.1038/cr.2016.93

[…] in the offspring were generated by talen-mediated mutagenesis., because talens may also cause off-target mutations,, we searched for any potential off-target mutations in the mcph1mt/mt monkey. talenoffer computational prediction tool was used to predict the possible off-target sites (otss) in the macaca fascicularis genome. thirteen potential otss with talenoffer score > −1.61 […]

PMCID: 4837413
PMID: 27095599
DOI: 10.1038/srep24652

[…] with mutant haplotypes each originating from a unique mutant haplotype in the g0 generation., potential off-target sites of talen9m10-3l and r in the c. quinquefasciatus genome were searched by talenoffer program. the options used were #n-terminal first: false, #n-terminal second: false, #hetero-dimers only: false, #architecture: min = 10, max = 30, #filter: q = 0.4, #rvd specificities: na. […]

PMCID: 4568496
PMID: 26365677
DOI: 10.1038/srep14057

[…] off-target sites. recently, tools for predicting talen off-targets have been developed, such as idtale (http://idtale.kaust.edu.sa), paired target finder (https://tale-nt.cac.cornell.edu), and talenoffer. compared with these, the advantage of our program is its simplicity and reliability. however, a more detailed investigation on the possible off-target effects of talens and more accurate […]


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TALENoffer institution(s)
Institute of Computer Science and Department of Genetics, Institute of Biology, Martin Luther University Halle-Wittenberg, Halle, Germany

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