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TANGO specifications


Unique identifier OMICS_03859
Software type Application/Script
Interface Command line interface
Restrictions to use None
Input data A protein sequence.
Output data An extensive sample of fragments for which competing structural propensities.
Operating system Unix/Linux
Computer skills Advanced
Stability Stable
Registration required Yes
Maintained Yes


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  • person_outline Luis Serrano <>

Publication for TANGO

TANGO in publications

PMCID: 5934419
PMID: 29725062
DOI: 10.1038/s41467-018-04203-x

[…] significantly differ in their destabilizing variant frequencies across passages (sitedestab). next, we calculated the effect of mutations on sequence aggregation propensity employing the widely used tango algorithm– (see methods and supplementary fig. ) in these same viral proteins to uncover p1 sites that differ in their ability to tolerate variants of increased aggregation propensity […]

PMCID: 5830399
PMID: 29491361
DOI: 10.1038/s41467-018-03131-0

[…] load in a murine bladder e. coli infection model, suggesting that redundant aprs in bacterial proteomes can be targeted for therapeutic purposes., we used the statistical thermodynamics algorithm tango to analyze the aggregation propensity and apr redundancy of the e. coli strain o157:h7 proteome. this yielded 3,535 apr sequences of at least six amino acids in length with a tango score […]

PMCID: 5766493
PMID: 29330519
DOI: 10.1038/s41598-017-18977-5

[…] of q/n rich regions was followed by the report by michelitsch and weissman, and the calculation was conducted by in-house perl scripts. the predicted aggregation propensity was calculated by tango 2.3, whose binary program was obtained from the website (http://tango.crg.es/). the prediction of intrinsically disordered regions was performed by dichot algorithm,. essentiality of each gene […]

PMCID: 5766897
PMID: 29375551
DOI: 10.3389/fimmu.2017.01860

[…] be optimized after rational introduction of proper hydrophilic amino acids for disruption of the large hydrophobic aggregation-prone clusters. in addition to sap (–), several online programs such as tango (–), pasta (), aggrescan (), and aggrescan3d () are also widely used to predict aggregation-prone regions within proteins. therefore, it is desired that new ig variants could be identified […]

PMCID: 5608858
PMID: 28935930
DOI: 10.1038/s41598-017-09714-z

[…] by papa, in all the above described proteins (figs  to )., the predicted soft amyloid cores for these proteins are shown in table . remarkably, well-validated aggregation predictors like aggrescan, tango and zyggregator failed to classify these stretches as aggregation-prone, the exception being the phc1 core, which was identified by tango (table ). the underlying reason explaining […]

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TANGO institution(s)
European Molecular Biology Laboratory, Heidelberg, Germany; SWITCH Laboratory, Flemish Institute for Biotechnology, Vrije Universiteit Brussel, Brussel, Belgium
TANGO funding source(s)
Supported by an EU Training and Mobility of Researchers grant (EU Network on amyloid fibril formation, CT2-00241).

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