Provides a data resource for analysis of tumor antigens and their functional sites. TANTIGEN is a comprehensive database of tumor T cell antigens that provides a catalog of previously published works and a repository of validated epitopes for cross-referencing newly discovered peptides. A training set for prediction of Human Leucocyte Antigen (HLA) binders that are naturally processed, and construction of models for prediction of T cell response to HLA binders are also available. The database includes a selection of bioinformatics tools for data analysis.
Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA, USA; School of Medicine and Bioinformatics Center, Nazarbayev University, Astana, Kazakhstan; Department of Computer Science, Metropolitan College, Boston University, Boston, MA, USA
TANTIGEN funding source(s)
Supported by The Danish Council for Independent Research Grant 4184-00211B), NIH Grant UO1 AI090043 and SU2C-AACR-DT13-14 and Dana-Farber Cancer Institute, Cancer Vaccine Center Funds.