Unlock your biological data
Chromatin immunoprecipitation coupled with deep sequencing (ChIP-seq) has great potential for elucidating transcriptional networks, by measuring genome-wide binding of transcription factors (TFs) at high resolution. Despite the precision of these experiments, identification of genes directly regulated by a TF (target genes) is not trivial.
(Sikora-Wohlfeld et al., 2013) Assessing computational methods for transcription factor target gene identification based on ChIP-seq data. PLoS Comput Biol.