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TargetHunter specifications


Unique identifier OMICS_04909
Name TargetHunter
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publication for TargetHunter

TargetHunter citations


A Computational Approach Using Bioinformatics to Screening Drug Targets for Leishmania infantum Species

PMCID: 5896251
PMID: 29785196
DOI: 10.1155/2018/6813467

[…] ture of the flavonoid was evaluated by applying distinct algorithms, which used chemical similarity to identify proteins with known ligands to show similarity to this molecule []. In the results, the TargetHunter, SwissTargetPrediction, SEA, and PASS servers identified 21, 15, 75, and 630 putative targets, respectively. A positive consensual result was obtained with three hits: NADPH oxidase, Aldo […]


Exploring G Protein Coupled Receptors (GPCRs) Ligand Space via Cheminformatics Approaches: Impact on Rational Drug Design

Front Pharmacol
PMCID: 5854945
PMID: 29593527
DOI: 10.3389/fphar.2018.00128

[…] lated receptors and ligands, along with cross-reactivities. As a result, the DA-KB became a powerful tool that has the capability of transforming data to useable polypharmacology knowledge. Moreover, TargetHunter server was also developed and can be used for target or off-target discovery. […]


The polypharmacology browser: a web based multi fingerprint target prediction tool using ChEMBL bioactivity data

J Cheminform
PMCID: 5319934
PMID: 28270862
DOI: 10.1186/s13321-017-0199-x

[…] on we successfully ran target predictions for CIS22a using six of the fourteen target prediction web-based tools listed in Table . Results comparable to PPB were obtained with SwissTarget, SuperPred, TargetHunter, ChemMapper and ChEMBLPred. On the other hand, SEA only returned a single, correct target, and PharmMapper did not predict any of the tested targets. […]


Characterization of anti leukemia components from Indigo naturalis using comprehensive two dimensional K562/cell membrane chromatography and in silico target identification

Sci Rep
PMCID: 4858665
PMID: 27150638
DOI: 10.1038/srep25491

[…] In this study, PharmMapper Server ( and TargetHunter ( tools were selected for potential drug target identification. PharmMapper server is a spatial arrangement of features essential for a molecule to i […]


One for All? Hitting Multiple Alzheimer's Disease Targets with One Drug

Front Neurosci
PMCID: 4842778
PMID: 27199640
DOI: 10.3389/fnins.2016.00177

[…] domain-specific chemogenomics database allowing the identification of off-target effects and the repurposing of compounds (Liu et al., ). AlzPlatform contains the established computational algorithm TargetHunter, which is an in silico target identification tool for small molecules (Wang et al., ).While there is a wealth of open access chemical information available to aid repurposing of FDA appro […]


Drug target identification using network analysis: Taking active components in Sini decoction as an example

Sci Rep
PMCID: 4837341
PMID: 27095146
DOI: 10.1038/srep24245

[…] alue, this protein was then considered as a potential target protein of this component. Second, the targets of components were searched in Herbal Ingredients’ Target (, TargetHunter Database (http://​www.​cbligand.​org/​TargetHunter), TCMID ( and CHEMBL ( by the structure of components. The potential targ […]

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TargetHunter institution(s)
Department of Pharmaceutical Sciences, School of Pharmacy, Computational Chemical Genomics Screening Center, Pittsburgh, PA, USA

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