TargetScan statistics

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Protocols

TargetScan specifications

Information


Unique identifier OMICS_00420
Name TargetScan
Alternative name TargetScanFly
Interface Web user interface
Restrictions to use None
Computer skills Basic
Version 7.2
Stability Stable
Maintained Yes
Wikipedia https://en.wikipedia.org/wiki/TargetScan

Taxon


  • Primates
    • Homo sapiens

Maintainers


  • person_outline TargetScan Team
  • person_outline David Bartel

Information


Unique identifier OMICS_00420
Name TargetScan
Alternative name TargetScanFly
Software type Pipeline/Workflow
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages C++, MATLAB, Perl, R, Shell (Bash)
License MIT License
Computer skills Advanced
Version 1.0.0
Stability Stable
Maintained Yes

Taxon


  • Primates
    • Homo sapiens

Download


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Versioning


No version available

Maintainers


  • person_outline TargetScan Team
  • person_outline David Bartel

Publications for TargetScan

TargetScan citations

 (1067)
call_split

A Five microRNA Signature for Survival Prognosis in Pancreatic Adenocarcinoma based on TCGA Data

2018
Sci Rep
PMCID: 5955976
PMID: 29769534
DOI: 10.1038/s41598-018-22493-5
call_split See protocol

[…] The target genes of the five-miRNA (miR-203, miR-424, miR-1266, miR-1293, and miR-4772) were predicted using TargetScan, miRDB, miRTarBase, and miRanda online analysis tools. To further enhance the reliability of the bioinformatic analysis, the overlapping target genes were identified using a Venn diagram. U […]

library_books

Direct measurement of pervasive weak repression by microRNAs and their role at the network level

2018
BMC Genomics
PMCID: 5952853
PMID: 29764374
DOI: 10.1186/s12864-018-4757-z

[…] d two relatively closely related species: D. simulans and D. yakuba. miR310s CDS targets are conserved between D.melanogaster and D.simulans. Transcripts targeted by miR310s were identified using the TargetScan algorithm [, , , ]. 3’UTR annotation was extracted from BDGP6.83. The whole genome alignments were dm6, droSim1, and droYak3 available at the UCSC Genome Browser. miRNA expression during th […]

library_books

LncRNA OIP5 AS1 is overexpressed in undifferentiated oral tumors and integrated analysis identifies as a downstream effector of stemness associated transcription factors

2018
Sci Rep
PMCID: 5935738
PMID: 29728583
DOI: 10.1038/s41598-018-25451-3

[…] e list of predicted genes cancer datasets from TCGA database was analyzed and downloaded using cBioportal and ChIPBase v2. online tools. Predictions of miRNA targets were performed and retrieved from TargetScan, miRanda, miRcode, Starbase and DIANA online prediction tools. For prediction of RNA-RNA interactions and RNA-RNA binding protein (RBPs) interaction, IntaRNA, and CLIPdb online tools were e […]

library_books

Analysis of the microRNA signature in left atrium from patients with valvular heart disease reveals their implications in atrial fibrillation

2018
PLoS One
PMCID: 5933750
PMID: 29723239
DOI: 10.1371/journal.pone.0196666

[…] ersely expressed to the altered miRNAs. There were no correlations between the number of binding sites in the 3’-UTR region and the mRNA fold changes. It has to be noticed that our analyses, based on TARGETSCAN predictions, did not take into account miRNA binding sites in the coding region of mRNAs. Highly targeted genes involved in TGF-beta and IGF-I pathways and miRNA functioning were predicted […]

library_books

LncRNA MT1JP functions as a ceRNA in regulating FBXW7 through competitively binding to miR 92a 3p in gastric cancer

2018
Mol Cancer
PMCID: 5930724
PMID: 29720189
DOI: 10.1186/s12943-018-0829-6

[…] P-wild not in MT1JP-mut in both SGC-7901 and BGC-823 cell lines, which indicated that miR-92a-3p is a target of lncRNA MT1JP (Fig. ). Further prediction of target genes of miR-92a-3p was performed by TargetScan (http://www.targetscan.org/vert_71/) and microRNA.org (http://www.microrna.org/microrna/home.do), and FBXW7 was selected as the target gene of miR-92a-3p for it acquired consistently highes […]

library_books

Long noncoding RNA DANCR promotes colorectal cancer proliferation and metastasis via miR 577 sponging

2018
PMCID: 5938019
PMID: 29717105
DOI: 10.1038/s12276-018-0082-5

[…] ious study, HSP27 was reported to be an miR-577 target. Thus, we investigated whether a similar ceRNA mechanism exists among DANCR, HSP27 and miR-577. Using the online theoretical prediction programs targetscan and lncbase, we found that DANCR and HSP27 shared the same miR-577 binding sites (at the transcription positions 424-430 in DANCR and 77-83 in HSP27) (Fig. ). Next, we confirmed that miR-57 […]

Citations

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TargetScan institution(s)
Whitehead Institute for Biomedical Research and Howard Hughes Medical Institute, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA
TargetScan funding source(s)
Supported by a National Science Foundation Graduate Research Fellowship, a National Institutes of Health (NIH) Medical Scientist Training Program fellowship T32GM007753, a European Molecular Biology Organization (EMBO) long-term fellowship, NIH grants GM067031 and GM118135, and by the Howard Hughes Medical Institute.

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