A manually curated database and platform of traditional medicinal plants with natural compounds that includes potential bio-target information. We gathered information on proteins that are related to or affected by medicinal plant ingredients and data on protein-protein interactions (PPIs). TarNet includes in-depth information on both plant-compound-protein relationships and PPIs. Additionally, TarNet can provide researchers with network construction analyses of biological pathways and PPIs associated with specific diseases. Researchers can upload a gene or protein list mapped to our PPI database that has been manually curated to generate relevant networks. Multiple functions are accessible for network topological calculations, subnetwork analyses, pathway analyses, and compound-protein relationships.
Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China; Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China; Zhongguancun Open Laboratory of the Research and Development of Natural Medicine and Health Products, Beijing, China
TarNet funding source(s)
This work was supported by the Major Scientific and Technological Special Project for ‘Significant New Drugs Formulation’ (Grant Numbers: 2015ZX09501001-001-003, 2012ZX09501001), the National Natural Science Foundation of China (Grant Numbers: 81374011), and the Special Project for National traditional Chinese medicine industry of China (Grant Numbers: 201507004).