TCM [email protected] statistics

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TCM [email protected] specifications

Information


Unique identifier OMICS_02736
Name TCM [email protected]
Restrictions to use None
Maintained Yes

Maintainer


  • person_outline Calvin Yu-Chian Chen

Additional information


http://tcm.cmu.edu.tw/about01.php?menuid=1

Publications for TCM [email protected]

TCM [email protected] citations

 (28)
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A systems pharmacology oriented discovery of a new therapeutic use of the TCM formula Liuweiwuling for liver failure

2018
Sci Rep
PMCID: 5884779
PMID: 29618826
DOI: 10.1038/s41598-018-21515-6
call_split See protocol

[…] ational Library of Medicine. For the drug target database construction, the chemical structure files (*.mol2) of the components in Liuweiwuling were collected from the open online databases including TCM [email protected] (TDT) and TCM-SP databases, and the putative targets of these compounds might act on were predicted by Pharmmapper via a molecular docking method towords the known human proteins ( […]

library_books

A Network Pharmacology Approach to Uncover the Multiple Mechanisms of Hedyotis diffusa Willd. on Colorectal Cancer

2018
PMCID: 5829364
PMID: 29619072
DOI: 10.1155/2018/6517034

[…] bChem [] (https://pubchem.ncbi.nlm.nih.gov/), as a public repository, provides information on chemical substances and their biological activities. We input all the active ingredients into PubChem and TCM [email protected] and got the 3D molecular structure files of all active compounds in HDW. Because the targets of the compounds without precise structural information cannot be successfully predicte […]

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Discovery of a Low Toxicity O GlcNAc Transferase (OGT) Inhibitor by Structure based Virtual Screening of Natural Products

2017
Sci Rep
PMCID: 5615061
PMID: 28951553
DOI: 10.1038/s41598-017-12522-0
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[…] e the same coordinate using a convenient docking box. A 22 × 22 × 22 Å box was set with the center next to the side chain of Pro559 to cover the UDP binding pocket of OGT.Nearly 61,000 compounds from TCM [email protected] were used as the ligand library. All molecules were predicted for ADME-Tox and other properties by the FAF-Drugs server. The whole library was filtered using the following properti […]

library_books

A corpus for plant chemical relationships in the biomedical domain

2016
BMC Bioinformatics
PMCID: 5029005
PMID: 27650402
DOI: 10.1186/s12859-016-1249-5

[…] ally collected from books, published results, and empirically widely known facts. One of the most representative databases containing plant–chemical relationships is the traditional Chinese medicine (TCM) [email protected] [], which is a 3D small molecular structure database of TCM for virtual screening or molecular simulation. Although this database currently contains 32,364 compounds from 352 diff […]

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In silico identification of anti cancer compounds and plants from traditional Chinese medicine database

2016
Sci Rep
PMCID: 4857115
PMID: 27145869
DOI: 10.1038/srep25462
call_split See protocol

[…] ive rate of 0.05. Thus CDRUG is effective to predict anti-cancer activity of the chemical compounds. In this study, we used the default (P < 0.05) cutoff in CDRUG to screen the 21334 compounds in the TCM [email protected].After anti-cancer activity prediction of the 21334 compounds, we measured whether a plant has potential ability to kill cancer cells using the method named ACEA. ACEA is based on t […]

library_books

Inhibitory effect of traditional oriental medicine derived monoamine oxidase B inhibitor on radioresistance of non small cell lung cancer

2016
Sci Rep
PMCID: 4764943
PMID: 26906215
DOI: 10.1038/srep21986

[…] To identify TOM-derived radiosensitizers, we first screened TOM-derived compounds for candidate NF-κB inhibitors. Structural information of active compounds in TOM provided by the TCM [email protected] was utilized. Of the active compounds observed in TOM, candidate NF-κB inhibitors were selected by searching two electronic literature databases (Pubmed and Web of Science). Using […]

Citations

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TCM [email protected] institution(s)
Department of Otolaryngology, China Medical University Hospital, Taichung, Taiwan; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan; School of Pharmacy, China Medical University, Taichung, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Laboratory of Computational and Systems Biology, China Medical University, Taichung, Taiwan; Department of Biotechnology, Asia University, Taichung, Taiwan; Department of Biomedical Informatics, Asia University, Taichung, Taiwan; China Medical University Beigang Hospital, Yunlin, Taiwan
TCM [email protected] funding source(s)
Supported by grants from the National Science Council of Taiwan (NSC101-2325-B-039-001), Asia University (100-asia-56); and China Medical University and Asia University (DMR-101-094); in part by Taiwan Department of Health Clinical Trial and Research Center of Excellence (DOH101-TD-B-111-004); and Taiwan Department of Health Cancer Research Center of Excellence (DOH101-TD-C-111-005).

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