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TcoF specifications


Unique identifier OMICS_01865
Name TcoF
Restrictions to use None
Maintained Yes


  • Primates
    • Homo sapiens

Publication for TcoF

TcoF citations


Single molecule real time (SMRT) sequencing comes of age: applications and utilities for medical diagnostics

Nucleic Acids Res
PMCID: 5861413
PMID: 29401301
DOI: 10.1093/nar/gky066

[…] etermine parent-of-origin alleles in embryos or patients (,). In a family having one child with Treacher Collins syndrome, SMRT amplicons sequencing was used to confirm the paternal transmission of a TCOF1 variant that affects splicing of the gene and potentially causes the disease (). For apparent de novo mutations that are a result of germ line mosaicism, determining the frequency of damaging al […]


A novel approach using long‐read sequencing and ddPCR to investigate gonadal mosaicism and estimate recurrence risk in two families with developmental disorders

Prenat Diagn
PMCID: 5725701
PMID: 28921562
DOI: 10.1002/pd.5156

[…] wed by variant calling using the Minor Variant Caller tool available in the SMRT analysis portal. A separate analysis was performed for each sample, and this revealed a total of five mutations in the TCOF1 transcript and one in the PTPN11 transcript. For each sample, high‐quality circular consensus (CCS) reads were then constructed using the Reads Of Insert plug‐in in the SMRT analysis portal. All […]


Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation

Nat Commun
PMCID: 4735750
PMID: 26792133
DOI: 10.1038/ncomms10328

[…] sed as an internal control. We analysed each band by densitometry with ImageJ software normalized against α-tubulin value to quantify the relative levels of P-ATM and γ-H2AX proteins in wild-type and Tcof1 mutant embryos. For Treacle in HeLa cells, qualify the relative levels of Treacle proteins in non-damaged and damaged cells with 10 Gy X-ray irradiation. […]


Cell fate determination by ubiquitin dependent regulation of translation

PMCID: 4602398
PMID: 26399832
DOI: 10.1038/nature14978

[…] only including the genomic positions 15 codons following the start codon and the position 5 codons preceding the stop codon. DESeq was used to calculate fold change enrichment of genes by KBTBD8 or TCOF1 knockdown at each time point after neural induction. […]


Development of a T Cell Receptor Targeting an HLA A*0201 Restricted Epitope from the Cancer Testis Antigen SSX2 for Adoptive Immunotherapy of Cancer

PLoS One
PMCID: 3969312
PMID: 24681846
DOI: 10.1371/journal.pone.0093321

[…] KFSEKISCV), SSX7 (KSLEKISYV), SSX8 (KYSEKISYV), SSX9 (KSSEKIIYV), SSX10 (KASEKILYV), IGSF22 (KESAKIFYD), ARHGAP1 (KFGQKIFYV), GPR82 (SCYEKIFYG), PHF8 (LKGEKIFYL), LIPM (TGQEKIYYV), SYT14 (IVGEKIFYL), TCOF1 (KASEKILQV), RBL2 (SPREKIFYY) and FRAS1 (SPREKIYYV) were synthesized by GenScript (Piscataway, NJ). Peptides were dissolved in DMSO and diluted in RPMI 1640 medium for loading of T2 cells. Bindi […]


Simplified Method for Predicting a Functional Class of Proteins in Transcription Factor Complexes

PLoS One
PMCID: 3709904
PMID: 23874789
DOI: 10.1371/journal.pone.0068857

[…] ases as described above.We have developed two models, Model 1 and Model 2, to recognize the nature of the binding partner of TFs. Model 1 aims at distinguishing if the binding partner of TF is “TF or TcoF” (TF/TcoF), or if it is “other” nuclear protein. Due to the fact that we have to ensure that Model 1 produces the same prediction score if the order of the bound TFs is TFa-TFb or TFb-TFa, Model […]


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TcoF institution(s)
Computational Bioscience Research Center, Thuwal, Saudi Arabia

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