TFactS protocols

View TFactS computational protocol

TFactS statistics

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TFactS specifications

Information


Unique identifier OMICS_11986
Name TFactS
Software type Application/Script
Interface Web user interface
Restrictions to use None
Input data Some up-regulated official gene names or Entrez gene IDs.
Programming languages Javascript, Perl, PHP, R
Database management system MySQL
Computer skills Basic
Stability Stable
Maintained Yes

Taxon


  • Primates
    • Homo sapiens

Maintainer


  • person_outline Jean-Baptiste Demoulin <>

Publications for TFactS

TFactS in pipelines

 (3)
2017
PMCID: 5289111
PMID: 28168095
DOI: 10.7717/peerj.2831

[…] were extracted as go annotation results, and the corrected p value (benjamini) was required to be no more than 0.05., the target genes of the up or down-regulated mirnas in mm were then submitted to tfacts database (), a site at: http://www.tfacts.org/. p-value, q-value, e-value and fdr were all applied for prediction of transcription factors, and only the transcription factor with these four […]

2017
PMCID: 5289111
PMID: 28168095
DOI: 10.7717/peerj.2831

[…] in multiple myeloma. then, the target genes for key mirnas were predicted by the software targetscan. additionally, functional enrichments and binding tfs were investigated by david database and tfacts database, respectively., firstly, comparing the normal tissues, 13 mirnas were differently expressed mirnas (dems) for at least three datasets. they were considered as key mirnas, with 12 […]

2017
PMCID: 5606074
PMID: 28927412
DOI: 10.1186/s12957-017-1244-y

[…] p values (p < 0.05) and then visualized as a heatmap. clustering of the heatmap was according to pearson correlation and average linkage., the key up- and downregulated mirnas were uploaded to tfacts database (http://www.tfacts.org/) [, ]. the transcription factors were predicted by p value, q value, e value, and fdr (each value is less than 0.05). the transcription factors regulated […]


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TFactS in publications

 (21)
PMCID: 5904183
PMID: 29666442
DOI: 10.1038/s41467-018-03959-6

[…] 162 regulated transcription factors (tfs) of which the potential core tfs controlling lec response to matrix stiffness were predicted based on up- and downregulated genes with the online resource tfacts (supplementary data ). these included the mechanosensitive gata2 transcription factor that was previously shown to regulate the lec response to shear stress,, and respond to ecm-derived […]

PMCID: 5739696
PMID: 29285309
DOI: 10.18632/oncotarget.22519

[…] regulated by 1,8-cineole treatment, we conducted a transcriptome analysis using an mrna microarray in hacat cells (uvb-only treated vs. uvb + 1,8-cineole-treated group). a bioinformatics tool, tfacts [] predicted that nf- κb (p = 0.00028) and stat1 (p = 0.0016) were transcription factors that could be regulated by 1,8-cineole in hacat cells (data not shown). however, further investigation […]

PMCID: 5606074
PMID: 28927412
DOI: 10.1186/s12957-017-1244-y

[…] p values (p < 0.05) and then visualized as a heatmap. clustering of the heatmap was according to pearson correlation and average linkage., the key up- and downregulated mirnas were uploaded to tfacts database (http://www.tfacts.org/) [, ]. the transcription factors were predicted by p value, q value, e value, and fdr (each value is less than 0.05). the transcription factors regulated […]

PMCID: 5424167
PMID: 28480889
DOI: 10.1038/ncomms15158

[…] set from a published transcriptomics study performed by oligonucleotide microarray at early time points post-infection with hcv (6, 12 and 24 h). we analysed the data sets from this report using tfacts, a program designed to predict which transcription factors are activated or inhibited based on the expression of their target genes in a microarray data set. the output of the tfacts analysis […]

PMCID: 5289111
PMID: 28168095
DOI: 10.7717/peerj.2831

[…] in multiple myeloma. then, the target genes for key mirnas were predicted by the software targetscan. additionally, functional enrichments and binding tfs were investigated by david database and tfacts database, respectively., firstly, comparing the normal tissues, 13 mirnas were differently expressed mirnas (dems) for at least three datasets. they were considered as key mirnas, with 12 […]


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TFactS institution(s)
de Duve Institute, Université Catholique de Louvain, Brussels, Belgium; Division of Hematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Bioinformatique des Génomes et des Réseaux (BIGRe), Université Libre de Bruxelles, Brussels, Belgium
TFactS funding source(s)
Région Wallonne de Belgique TransMaze project (415925 linked to 516207); ‘Bourse d’Excellence IN.WBI’ from Wallonie-Bruxelles International, Belgium.

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