Facilitates multiple genotyping formats. TGS-TB is a web-based application that uses next-generation sequencing (NGS) for the analysis of phylogenies with (i) core genomic single nucleotide variations (SNVs), (ii) linkage network analysis of outbreak strains, (iii) spoligotyping, (iv) the analysis of IS6110 insertion sites and (v) variable number tandem repeat (VNTR). It also includes the prediction of Mycobacterium tuberculosis complex (MTBC) lineages/sub-lineages and potential antimicrobial resistance (AMR) based on the KvarQ script.
Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan; Molecular Epidemiology Division, The Research Institute of Tuberculosis/Japan Anti-Tuberculosis Association, Tokyo, Japan; Department of Infectious Diseases, Kobe Institute of Health, Kobe, Japan; Bacteriology Division, Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan; Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan
TGS-TB funding source(s)
Supported by a Grant in-Aid for Research on Emerging and Re-emerging Infectious Diseases (H25-Shinko-Ippan-015) from the Ministry of Health Labour and Welfare Programs of Japan, and by Research Program on Emerging and Re-emerging Infectious Diseases (15fk0108011h0003 and 15fk0108004h0001) from Japan Agency for Medical Research and development, AMED.