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The Sulfinator specifications

Information


Unique identifier OMICS_02436
Name The Sulfinator
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Documentation


Maintainer


  • person_outline Elisabeth Gasteiger

Publication for The Sulfinator

The Sulfinator citations

 (6)
library_books

Sendai virus recruits cellular villin to remodel actin cytoskeleton during fusion with hepatocytes

2017
Mol Biol Cell
PMCID: 5739296
PMID: 29074568
DOI: 10.1091/mbc.E17-06-0400

[…] antibody was observed in fusion samples, which suggested a posttranslational modification (, top row, green arrow). the possibilities of glycosylation and sulfation were less likely, as examined by the sulfinator tool (expasy) and supported by published literature (). further, an increase in villin was associated with an increase in the intensity of phosphorylated erk levels in the fusion […]

library_books

Isolation, production and characterization of fully human monoclonal antibodies directed to Plasmodium falciparum MSP10

2015
Malar J
PMCID: 4502606
PMID: 26174014
DOI: 10.1186/s12936-015-0797-x

[…] complementarity determining regions (cdrs) were identified according to the kabat rules []. alignments were done with clustal omega []. potential sulfation of tyrosine residues was predicted by the sulfinator algorithm []., all enzymes for cloning purposes were obtained from neb (frankfurt am main, germany). amplicons from v regions were cloned into ptrakt plant expression vectors. […]

library_books

Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies

2015
PLoS Genet
PMCID: 4488434
PMID: 26131556
DOI: 10.1371/journal.pgen.1005344

[…] tree. motif search was performed with motif scan [], scansite 2.0 scan motif [], scan prosite (expasy), interproscan 4 [], pfam [], and smart 6 []. protein modification scan was performed using the sulfinator (expasy) for sulfination and yinoyang [] for glycosylation and phosphorylation., genome-edited mice were generated essentially as described [, ]. briefly, in-vitro synthesized cas9 […]

library_books

The 3′ Phosphoadenosine 5′ Phosphosulfate Transporters, PAPST1 and 2, Contribute to the Maintenance and Differentiation of Mouse Embryonic Stem Cells

2009
PLoS One
PMCID: 2788424
PMID: 20011239
DOI: 10.1371/journal.pone.0008262

[…] residues on proteins. the sulfation of proteins occurs on specific tyrosine residues as they enter the secretory pathway. however, according to sulfation consensus prediction algorithms (e.g. the sulfinator) , the relevant extrinsic factors, such as wnt3a, bmp2, bmp4 and several fgfs, are not predicted to be substrates for tyrosine sulfation. this suggests that the reduction in signaling […]

library_books

Predicting sulfotyrosine sites using the random forest algorithm with significantly improved prediction accuracy

2009
BMC Bioinformatics
PMCID: 2777180
PMID: 19874585
DOI: 10.1186/1471-2105-10-361

[…] and 33 unconfirmed sulfotyrosine sites in 15 blind test sequences. two inferred sulfotyrosine sites were not used for the evaluation. table shows the prediction result for these sequences using the sulfinator. in the table, "actual" means the experimentally verified sulfotyrosine sites while "predicted" means the predicted sulfotyrosine sites. "accession" is the accession number from ncbi […]

library_books

Incomplete posttranslational prohormone modifications in hyperactive neuroendocrine cells

2009
BMC Cell Biol
PMCID: 2689178
PMID: 19422674
DOI: 10.1186/1471-2121-10-35

[…] through n-glycans., deglycosylation of [35s]sulphate labelled 37 k pomc with pngasef did not reduce its level (figure ), indicating that xenopus pomc is not glyco- but rather tyrosine-sulphated. the sulfinator prediction program [] indeed predicts a sulphation site on tyrosine residue 188 (sleldy188peidldedied) in the c-terminal half of xenopus 37 k pomc., deglycosylation with endoh revealed […]


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The Sulfinator institution(s)
SWISS-PROT Group, Swiss Institute of Bioinformatics, CMU, Geneva, Switzerland

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