TherMos specifications


Unique identifier OMICS_00498
Name TherMos
Alternative name THERmodynamic MOdeling of ChIP-Seq
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages MATLAB
Computer skills Advanced
Stability Stable
Maintained Yes




No version available


  • person_outline Shyam Prabhakar
  • person_outline Ralf Jauch

Publication for THERmodynamic MOdeling of ChIP-Seq

TherMos citation


Integrative model of genomic factors for determining binding site selection by estrogen receptor α

Mol Syst Biol
PMCID: 3018168
PMID: 21179027
DOI: 10.1038/msb.2010.109

[…] and full sites of the ∼16,000 ERα binding regions, we fitted a widely used thermodynamic model of TF–DNA binding to the ChIP-seq data (; ).Our model was constructed by applying a new algorithm called Thermodynamic Modeling of chip-Seq (TherMoS) (Sun et al, manuscript in preparation; MATLAB code available upon request). The algorithm employs nonlinear regression to fit the observed distribution of […]

TherMos institution(s)
Computational and Systems Biology, Genome Institute of Singapore, Singapore, Singapore; Laboratory for Structural Biochemistry, Genome Institute of Singapore, Singapore, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore; Division of Molecular Neurobiology, Medical Research Council National, Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
TherMos funding source(s)
Supported by Joint Council Office of the Agency for Science, Technology and Research, Singapore [JCOAG03_FG02_2009].

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