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THERmodynamic MOdeling of ChIP-Seq TherMos

Estimates protein–DNA binding energies from in vivo binding profiles. TherMos is a position specific energy matrix (PSEM) estimation method. The software infers an additive binding energy model using least-squares fitting to the ChIP-seq tag profile. TherMos fits to the peak shape in binding regions, rather than to absolute peak height. It can also be used on ChIP-exo data, which provides even higher spatial resolution than ChIP-seq.

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TherMos classification

TherMos specifications

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TherMos distribution


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TherMos support


  • Shyam Prabhakar <>
  • Ralf Jauch <>


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Computational and Systems Biology, Genome Institute of Singapore, Singapore, Singapore; Laboratory for Structural Biochemistry, Genome Institute of Singapore, Singapore, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore; Division of Molecular Neurobiology, Medical Research Council National, Institute for Medical Research, The Ridgeway, Mill Hill, London, UK

Funding source(s)

Supported by Joint Council Office of the Agency for Science, Technology and Research, Singapore [JCOAG03_FG02_2009].

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