Identifies thiopeptide biosynthetic gene clusters in the user-supplied nucleotide or genomic sequences. ThioFinder is a web-based tool that works with an open-access database named ThioBase. It employs the multiple features of thiopeptide biosynthetic machinery, including the ribosomal precursor peptide and the highly conserved partners for the thiopeptide-specific posttranslational modifications. It utilizes a Hidden Markov Models (HMMs)-based approach to automatically predict thiopeptide biosynthetic gene clusters.
State Key Laboratory of Microbial Metabolism, Shanghai Jiaotong University, Shanghai, China; State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
ThioFinder funding source(s)
Supported in part by grants from the National Natural Science Foundation of China; the Ministry of Science and Technology of China (973 and 863 Programs); the Program for New Century Excellent Talents in University, Ministry of Education of China [NCET-10-0572]; the Chen Xing Young Scholars Program, Shanghai Jiaotong University; and Shanghai Municipality.