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TiGER specifications


Unique identifier OMICS_06111
Name TiGER
Alternative name Tissue-specific Gene Expression and Regulation
Restrictions to use None
Community driven No
Data access File download, Browse
User data submission Not allowed
Maintained Yes


  • Primates
    • Homo sapiens


  • person_outline Jiang Qian
  • person_outline Xiong Liu
  • person_outline Xueping Yu
  • person_outline Donald Zack
  • person_outline Heng Zhu

Publication for Tissue-specific Gene Expression and Regulation

TiGER citations


Genetic variants in cellular transport do not affect mesalamine response in ulcerative colitis

PLoS One
PMCID: 5868763
PMID: 29579042
DOI: 10.1371/journal.pone.0192806

[…] c variants in genes involved in solute and drug transport. The list of transporter genes was further focused to only genes showing expression within the colonic mucosa based on expression profiles in Tissue specific Gene Expression and Regulation database (TiGER).[] Utilization of the TiGER database restricted the genes of analysis to 47 (see ). Genetic variants were analyzed for variants with min […]


HLA G Haplotypes Are Differentially Associated with Asthmatic Features

Front Immunol
PMCID: 5829031
PMID: 29527207
DOI: 10.3389/fimmu.2018.00278
call_split See protocol

[…] iation with the AliBaba 2.1 and ConSite programs. TFs found to have differential binding sites between HLA-G haplotypes were checked for their tissue-specific expression (blood and lungs) in NCBI and Tissue-specific Gene Expression and Regulation (TiGER) databases (). NCBI data included the “HPA RNA-seq normal tissues” project, i.e., RNA-seq performed on 27 different tissue samples from 95 human i […]


Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole exome sequencing

Eur J Hum Genet
PMCID: 5643972
PMID: 28875981
DOI: 10.1038/ejhg.2017.138
call_split See protocol

[…] 064) and TLR pathway (entry 04620) to select variants known to predispose to immunodeficiencies. As a fourth criterion, we selected genes with a high expression in the stomach (based on data from the Tissue-specific Gene Expression and Regulation (TiGER) database). The combined gene list for the categories mentioned above can be found in .The National Heart, Lung, and Blood Institute (NHLBI) Exome […]


Epistatic Gene Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium

PLoS Genet
PMCID: 5021356
PMID: 27623284
DOI: 10.1371/journal.pgen.1006186

[…] s.As additional follow-up, we explored which of the 33 unique genes comprising the 17 unique gene-gene models (described above) showed evidence of expression in eye tissue using two online databases: Tissue-specific Gene Expression and Regulation (TiGER) and BioGPS[]. shows a gene-gene interaction circular plot among the 33 unique genes color-coded by the genes that are expressed (red) and not exp […]


Codon optimization of the adenoviral fiber negatively impacts structural protein expression and viral fitness

Sci Rep
PMCID: 4899721
PMID: 27278133
DOI: 10.1038/srep27546

[…] enomes.urv.es/CAIcal. Homo sapiens codon usage extracted from the Codon Usage Database was utilized as the reference value to perform the calculations. The human genes analyzed were selected from the Tissue-specific Gene Expression And Regulation database at the Johns Hopkins University. All calculated codon usage and CAI values are available in . In order to analyze CAI distribution along the sec […]


Identification of Circulating Biomarker Candidates for Hepatocellular Carcinoma (HCC): An Integrated Prioritization Approach

PLoS One
PMCID: 4586137
PMID: 26414287
DOI: 10.1371/journal.pone.0138913

[…] f ≥ 1.96 that reveals 95% confidence level of enrichment were included. Proteins without a SymAtlas z-score were ignored. The TiGER database [] which provides and summarizes large scale data sets for tissue-specific gene expression and regulation in a variety of human tissues was used for proteins preferentially expressed in liver based on ESTs by searching liver tissue using ‘Tissue View’. The Ti […]

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TiGER institution(s)
Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
TiGER funding source(s)
Supported by the National Institutes of Health (EY017589, GM076102, and EY001765), and by Mr. and Mrs. Robert and Clarice Smith through a generous gift.

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