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TIMBAL specifications


Unique identifier OMICS_10183
Restrictions to use None
Version 2.0
Maintained Yes


  • person_outline Alicia P. Higueruelo

Publications for TIMBAL

TIMBAL citations


Imbalance in chemical space: How to facilitate the identification of protein protein interaction inhibitors

Sci Rep
PMCID: 4817116
PMID: 27034268
DOI: 10.1038/srep23815

[…] ve been observed fewer than 15 times. The present PAINS analysis indicates that iPPIs tend to show on average more PAINS-containing compounds (20% for iPPI-DB, mostly from filter PAINS-C, and 15% for TIMBAL, mostly from filter PAINS-A) than active compounds on conventional targets (less than 10%, except for kinase with 15%). Nevertheless, this pattern is not the case for all of the PPI targets. In […]


Composition of Overlapping Protein Protein and Protein Ligand Interfaces

PLoS One
PMCID: 4627654
PMID: 26517868
DOI: 10.1371/journal.pone.0140965

[…] .g. [,–]. Comparing these features of protein interfaces to those of overlapping protein-ligand interfaces should aid in targeting protein-protein interaction sites. Here, we used the ABC, PIBASE and Timbal databases as data sources for protein interfaces and surfaces. All three databases are secondary database that are derived from the PDB. However, due to the different way of identifying overlap […]


Using a Fragment Based Approach To Target Protein–Protein Interactions

PMCID: 3594973
PMID: 23344974
DOI: 10.1002/cbic.201200521

[…] ler et al. to demonstrate key differences in the nature of PPIs and other protein–ligand interactions.[] Hand-curated databases of protein:protein complexes and their inhibitors, such as 2P2IDB[] and TIMBAL,[] have been constructed to facilitate the specific study of protein–protein interactions. Further to these, experimental approaches to druggability have been developed based upon a correlation […]


A new species of the cicada genus Cicadatra Kolenati, 1857 (Hemiptera, Cicadidae) from Pakistan with a key to the known species of Pakistani Cicadatra

PMCID: 3307353
PMID: 22451783
DOI: 10.3897/zookeys.174.2299

[…] ings with radial and radiomedial crossveins at bases of the 2nd and 3rd apical cells infuscated in Cicadatra ziaratica but lacking infuscation in Cicadatra lorestanica and Cicadatra karachiensis. The timbal cover of Cicadatra karachiensis is reduced and ventral to the majority of the timbal while the timbal cover in Cicadatra ziaratica and Cicadatra lorestanica covers more than half the timbal and […]


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TIMBAL institution(s)
Department of Biochemistry, University of Cambridge, Cambridge, UK
TIMBAL funding source(s)
This work was supported by the University of Cambridge, BBSRC and UCB.

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