Includes information on 5153 putative drug–target pairs for 150 human pathogens derived from available drug–target crystallographic complexes. The TIPs database has been developed with the aim of facilitating the identification of new therapeutic targets in organisms responsible for human infections. All entries are thoroughly annotated with both sequence and functional information. The database can be queried by organism name, protein family or function. The query returns a sortable table providing information about both known and predicted drug–target pairs and links to visualize specific information on the drug(s) physicochemical properties, structure, indication and side effects, the target(s) and to visually analyse or download their 3D complexes.
Department of Physics, Sapienza University, Rome, Italy; Center for Life Nano Science Sapienza, Istituto Italiano di Tecnologia, Rome, Italy; Istituto Pasteur, Fondazione Cenci Bolognetti, Sapienza University, Rome, Italyy
TiPs funding source(s)
This work was supported by the King Abdullah University of Science and Technology (KAUST), Award No. KUK-I1-012-43, PRIN 20108XYHJS and FIRB RBIN06E9Z8_005.
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