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TiSAn specifications


Unique identifier OMICS_18663
Name TiSAn
Alternative name Tissue-Specific Annotation
Software type Framework/Library, Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages R
License MIT License
Computer skills Advanced
Stability Stable
Maintained Yes



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  • person_outline Jacob Michaelson <>

Publication for Tissue-Specific Annotation

TiSAn in publications

PMCID: 5805369
PMID: 29377896
DOI: 10.1371/journal.pgen.1007186

[…] we randomly selected 10 non-adjacent blocks as causal blocks and we randomly selected 20% snps inside these causal blocks to be causal snps (i.e. a total of 200 causal snps). we then simulated ten tissue-specific annotation sets, each with two annotations, which are simulated to correlate with snp causality []. specifically, the annotation values for the non-causal snps are sampled […]

PMCID: 5138592
PMID: 27922122
DOI: 10.1038/srep38588

[…] therefore they appear to be involved in more biological processes. this bias is present in any manually annotated pathway or biological database. as not all proteins listed in signalink 2 had tissue-specific annotation, we also conducted an analysis incorporating the unannotated proteins to every tissue (generating potential false positives with lesser known proteins but decreasing false […]

PMCID: 4772325
PMID: 26926147
DOI: 10.1186/s12864-016-2482-z

[…] expression patterns (wilcoxon p < 10−8). this consistency is striking given that the rna-seq data includes information about later embryonic stages not assayed in the imaging data. thus, known tissue-specific annotation and expression patterns support the idea that genes which occur in a given cluster are expressed in a similar set of embryonic cells., we further validated the clusters […]

PMCID: 4764260
PMID: 26901046
DOI: 10.1371/journal.pgen.1005875

[…] the association. as an example, the enrichment for ldl level-associated snps is 9.1-fold higher among snps predicted to affect hnf4 binding sites than in a background model already including tissue-specific annotation., a large fraction of genetic variants that have been associated with complex traits are found outside of protein coding genes and likely affect gene regulation. many […]

PMCID: 4327067
DOI: 10.3390/s150101106

[…] steven j.thoonen, g.thouand, geraldthoury, mathieutian, fengchuntian, guiyuntian, wei-chengtian, yutidoni, emmanueletie, litiloca, marcotimmermann, dirktimotheou, steliostimpe, shannon jting, lena h.tisan, alintisch, ulriketisseyre, brunotittel, francktjin, swee chuantofighi, mohammadtognetti, alessandrotollefsen, dagtomarchio, oraziotomás, juantomasi, riccardotomažič, sašotomkiewicz, […]

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TiSAn institution(s)
University of Iowa, Carver College of Medicine, Iowa City, IA, USA; Department of Psychiatry, Carver College of Medicine, Iowa City, IA, USA
TiSAn funding source(s)
Supported by NIH grants MH105527 and DC014489.

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