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TiSGeD specifications


Unique identifier OMICS_11271
Name TiSGeD
Alternative name Tissue-Specific Genes Database
Restrictions to use None
Data access Browse
Maintained Yes


  • Primates
    • Homo sapiens
  • Rodents
    • Mus musculus
    • Rattus norvegicus


  • person_outline Zhi-Liang Ji

Publication for Tissue-Specific Genes Database

TiSGeD citations


A benchmark of gene expression tissue specificity metrics

Brief Bioinform
PMCID: 5444245
PMID: 26891983
DOI: 10.1093/bib/bbw008
call_split See protocol

[…] stance from the mean is used, so that under-expressed genes are also defined as tissue specific. Only the former method was used to be able to compare z-score with other methods.SPM from the database TiSGeD [] was calculated as follows: SPM=xi2∑i=1nxi2.PEM estimates how different the expression of the gene is relative to an expected expression, under the assumption of uniform expression in all tis […]


Analysis of spatial temporal gene expression patterns reveals dynamics and regionalization in developing mouse brain

Sci Rep
PMCID: 4726224
PMID: 26786896
DOI: 10.1038/srep19274

[…] nexpressed relative to other substructures over all time points.The quantization procedure is robust against data normalization procedures such as z-scores, rank transform, PaGeFinder, PaGenBase, and TiSGeD since the threshold was obtained from the sorted data point values and the order of data point values is preserved in most normalization procedures. […]


Lung Cancer Signature Biomarkers: tissue specific semantic similarity based clustering of Digital Differential Display (DDD) data

BMC Res Notes
PMCID: 3532198
PMID: 23122428
DOI: 10.1186/1756-0500-5-617

[…] To identify lung tissue specific clusters from the 202 genes from DDD2 cancerous condition, firstly they were subjected to similarity clustering analysis using the 47 lung tissue specific genes from TiSGeD (See Additional file ). Before the semantic similarity clustering analysis, the Unigene ID were converted into Entrez ID. During this process, the 202 genes of DDD2 reduced to 145 and the 47 lu […]


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TiSGeD institution(s)
Key Laboratory for Cell Biology and Tumor Cell Engineering, the Ministry of Education of China, School of Life Sciences, Xiamen University, Xiamen, Fujian, China; The Key Laboratory for Chemical Biology of Fujian Province, School of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, China
TiSGeD funding source(s)
The support from the National Natural Science Foundation of China (NSFC#30873159), the Program for New Century Excellent Talents (NCET) of MOE and the Science Planning Program of Fujian Province (2009J1010) are gratefully acknowledged.

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