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A major challenge of microarray analysis is to detect genes whose expression in a single or small number of tissues is significantly different than in other tissues. Accurate identification of such tissue-specific genes can allow researchers to deduce the function of their tissues and organs at the molecular level (Greller and Tobin, 1999).
(Greller and Tobin, 1999) Detecting selective expression of genes and proteins. Genome Res.
(Kadota et al., 2006) ROKU: a novel method for identification of tissue-specific genes. BMC Bioinformatics.