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ESTIMATE / Estimation of STromal and Immune cells in MAlignant Tumors using Expression data
Uses gene expression signature to infer the fraction of stromal and immune cells in tumor tissues. ESTIMATE scores correlate with DNA copy number-based tumour purity across samples from 11 different tumour types, profiled on Agilent, Affymetrix platforms or based on RNA sequencing and available through The Cancer Genome Atlas. The prediction accuracy is further corroborated using 3,809 transcriptional profiles available elsewhere in the public domain. The ESTIMATE method allows consideration of tumour-associated normal cells in genomic and transcriptomic studies.
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