TITAN statistics

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Associated diseases

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TITAN specifications

Information


Unique identifier OMICS_05917
Name TITAN
Alternative name TITANCNA
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
Computer skills Advanced
Stability Stable
Maintained Yes

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Maintainer


  • person_outline Sohrab P. Shah <>

Publication for TITAN

TITAN in publications

 (2)
PMCID: 5814445
PMID: 29449575
DOI: 10.1038/s41467-017-02688-6

[…] purities >98% and contamination rates <2% in germline isolates (supplementary fig. ). this high purity, together with the generally diploid karyotype of t-pll cells (overall cn 1.97 based on titancna and the 17 t/g wes pairs) facilitated specific somatic calls and reliable calculations of variant allele fractions (vafs) and cellular prevalences (formerly ‘cancer cell fractions’ (ccfs)) […]

PMCID: 5643198
PMID: 28581503
DOI: 10.1038/ng.3891

[…] fashion to assess the confidence (in detected samples) and evidence (in un-detected samples) for the alternative allele (). somatic copy number alterations and tumor purity (p) were estimated with titancna (version 1.8.0) in exome-seq mode (except for the esca dataset where wgs was available). the observed vaf for each detected somatic snv was adjusted based on ccf (cancer cell fraction) […]


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TITAN institution(s)
Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada; Bioinformatics Training Program, University of British Columbia, Vancouver, BC, Canada; Centre for Translational and Applied Genomics, Vancouver, BC, Canada; Department of Computer Science, University of British Columbia, Vancouver, BC, Canada; Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada; Genetic Pathology Evaluation Centre, Vancouver General Hospital, Vancouver, BC, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Gynecology and Obstetrics, University of British Columbia, Vancouver, BC, Canada
TITAN funding source(s)
Supported by the Natural Sciences and Engineering Research Council of Canada.

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