bookmark CCTOP / Consensus Constrained TOPology prediction star_border star_border star_border star_border star_border star star star star star (1) A web-based application providing transmembrane topology prediction. In addition to utilizing 10 different state-of-the-art topology prediction methods, the CCTOP server incorporates topology information from existing experimental and computational sources available in the PDBTM, TOPDB and TOPDOM databases using the probabilistic framework of hidden Markov model. The server provides the option to precede the topology prediction with signal peptide prediction and transmembrane-globular protein discrimination. Given the amino acid sequence of a putative α-helical transmembrane protein, CCTOP predicts its topology i.e. localization of membrane spanning regions and orientation of segments between them. The prediction results and the collected experimental information are visualized on the CCTOP home page and can be downloaded in XML format.