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TMpro specifications

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Unique identifier OMICS_07202
Name TMpro
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability No
Maintained No

Publication for TMpro

TMpro citations

 (12)
library_books

Cebpd Is Essential for Gamma Tocotrienol Mediated Protection against Radiation Induced Hematopoietic and Intestinal Injury

2018
PMCID: 5946121
PMID: 29642403
DOI: 10.3390/antiox7040055

[…] in the radioprotection of hematopoietic and intestinal injury by gt3 that may be mediated by cebpd. similar to our findings, a recent study revealed increased bone marrow injury and lethality in tmpro/− mice, despite the expression of high g-csf levels in response to ir and gt3 in combination []. there is no evidence in the literature for g-csf as an inducer of cebpd, although other family […]

library_books

Thrombomodulin Contributes to Gamma Tocotrienol Mediated Lethality Protection and Hematopoietic Cell Recovery in Irradiated Mice

2015
PMCID: 4393275
PMID: 25860286
DOI: 10.1371/journal.pone.0122511

[…] after 5 μm gt3 treatment for 4 hr). in vivo survival studies showed that gt3 was significantly more effective as a radioprotector in tm wild type (tm+/+) mice than in mice with low tm function (tmpro/-). after exposure to 9 gy tbi, gt3 pre-treatment conferred 85% survival in tm+/+ mice compared to only 50% in tmpro/-. thus, gt3-mediated radiation lethality protection is partly dependent […]

library_books

Role of Tissue Factor in Mycobacterium tuberculosis Induced Inflammation and Disease Pathogenesis

2014
PMCID: 4252100
PMID: 25462128
DOI: 10.1371/journal.pone.0114141

[…] had no significant impact on the inflammatory response induced by m.tb . in an earlier study, the same group of investigators reported that mice with a mutation in thrombomodulin (tm) gene (tmpro/pro), which reduces apc generation, showed uncontrolled lung inflammation, elevated levels of pro-inflammatory cytokines, and higher bacterial dissemination to liver and spleen . despite […]

library_books

A Thrombomodulin Mutation that Impairs Active Protein C Generation Is Detrimental in Severe Pneumonia Derived Gram Negative Sepsis (Melioidosis)

2014
PMCID: 3998929
PMID: 24762740
DOI: 10.1371/journal.pntd.0002819

[…] (pneumo)sepsis in south-east asia caused by burkholderia (b.) pseudomallei., (wt) mice and mice with an impaired capacity to activate protein c due to a point mutation in their thbd gene (tmpro/pro mice) were intranasally infected with b. pseudomallei and sacrificed after 24, 48 or 72 hours for analyses. additionally, survival studies were performed. when compared to wt mice, […]

library_books

The Discovery of Dabigatran Etexilate

2013
PMCID: 3569592
PMID: 23408233
DOI: 10.3389/fphar.2013.00012

[…] stability, improved endothelial function, and reduced oxidative stress (preusch et al., ; kadoglou et al., ; lee et al., ). another study in a procoagulant/atherosclerotic mouse model (apoe−/−:tmpro/pro) having elevated coagulation activity due to a loss-of-function mutation in tm demonstrated that dabigatran significantly reduced plaque area and stenosis after a carotid cuff injury […]

library_books

Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil Dependent Manner

2013
PMCID: 3567111
PMID: 23409043
DOI: 10.1371/journal.pone.0055784

[…] associated with significant qualitative benefits, including diminished leukocyte infiltration, altered collagen and vascular smooth muscle cell content. genetically-imposed hypercoagulability in tmpro/pro:apoe−/− mice resulted in severe atherosclerosis, plaque vulnerability and spontaneous atherothrombosis. hypercoagulability was associated with a pronounced neutrophilia, neutrophil […]


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TMpro institution(s)
Language Technologies Institute, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA; School of Information Sciences, University of Pittsburgh, Pittsburgh, PA, USA; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

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