TMpro

[…] in the radioprotection of hematopoietic and intestinal injury by gt3 that may be mediated by cebpd. similar to our findings, a recent study revealed increased bone marrow injury and lethality in tmpro/− mice, despite the expression of high g-csf levels in response to ir and gt3 in combination []. there is no evidence in the literature for g-csf as an inducer of cebpd, although other family […]

[…] after 5 μm gt3 treatment for 4 hr). in vivo survival studies showed that gt3 was significantly more effective as a radioprotector in tm wild type (tm+/+) mice than in mice with low tm function (tmpro/-). after exposure to 9 gy tbi, gt3 pre-treatment conferred 85% survival in tm+/+ mice compared to only 50% in tmpro/-. thus, gt3-mediated radiation lethality protection is partly dependent […]

[…] had no significant impact on the inflammatory response induced by m.tb . in an earlier study, the same group of investigators reported that mice with a mutation in thrombomodulin (tm) gene (tmpro/pro), which reduces apc generation, showed uncontrolled lung inflammation, elevated levels of pro-inflammatory cytokines, and higher bacterial dissemination to liver and spleen . despite […]

[…] (pneumo)sepsis in south-east asia caused by burkholderia (b.) pseudomallei., (wt) mice and mice with an impaired capacity to activate protein c due to a point mutation in their thbd gene (tmpro/pro mice) were intranasally infected with b. pseudomallei and sacrificed after 24, 48 or 72 hours for analyses. additionally, survival studies were performed. when compared to wt mice, […]

[…] stability, improved endothelial function, and reduced oxidative stress (preusch et al., ; kadoglou et al., ; lee et al., ). another study in a procoagulant/atherosclerotic mouse model (apoe−/−:tmpro/pro) having elevated coagulation activity due to a loss-of-function mutation in tm demonstrated that dabigatran significantly reduced plaque area and stenosis after a carotid cuff injury […]

[…] associated with significant qualitative benefits, including diminished leukocyte infiltration, altered collagen and vascular smooth muscle cell content. genetically-imposed hypercoagulability in tmpro/pro:apoe−/− mice resulted in severe atherosclerosis, plaque vulnerability and spontaneous atherothrombosis. hypercoagulability was associated with a pronounced neutrophilia, neutrophil […]