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TMpro specifications


Unique identifier OMICS_07202
Name TMpro
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability No
Maintained No

Publication for TMpro

TMpro citations


Cebpd Is Essential for Gamma Tocotrienol Mediated Protection against Radiation Induced Hematopoietic and Intestinal Injury

PMCID: 5946121
PMID: 29642403
DOI: 10.3390/antiox7040055

[…] in the radioprotection of hematopoietic and intestinal injury by gt3 that may be mediated by cebpd. similar to our findings, a recent study revealed increased bone marrow injury and lethality in tmpro/− mice, despite the expression of high g-csf levels in response to ir and gt3 in combination []. there is no evidence in the literature for g-csf as an inducer of cebpd, although other family […]


Thrombomodulin Contributes to Gamma Tocotrienol Mediated Lethality Protection and Hematopoietic Cell Recovery in Irradiated Mice

PMCID: 4393275
PMID: 25860286
DOI: 10.1371/journal.pone.0122511

[…] after 5 μm gt3 treatment for 4 hr). in vivo survival studies showed that gt3 was significantly more effective as a radioprotector in tm wild type (tm+/+) mice than in mice with low tm function (tmpro/-). after exposure to 9 gy tbi, gt3 pre-treatment conferred 85% survival in tm+/+ mice compared to only 50% in tmpro/-. thus, gt3-mediated radiation lethality protection is partly dependent […]


Role of Tissue Factor in Mycobacterium tuberculosis Induced Inflammation and Disease Pathogenesis

PMCID: 4252100
PMID: 25462128
DOI: 10.1371/journal.pone.0114141

[…] had no significant impact on the inflammatory response induced by m.tb . in an earlier study, the same group of investigators reported that mice with a mutation in thrombomodulin (tm) gene (tmpro/pro), which reduces apc generation, showed uncontrolled lung inflammation, elevated levels of pro-inflammatory cytokines, and higher bacterial dissemination to liver and spleen . despite […]


A Thrombomodulin Mutation that Impairs Active Protein C Generation Is Detrimental in Severe Pneumonia Derived Gram Negative Sepsis (Melioidosis)

PMCID: 3998929
PMID: 24762740
DOI: 10.1371/journal.pntd.0002819

[…] (pneumo)sepsis in south-east asia caused by burkholderia (b.) pseudomallei., (wt) mice and mice with an impaired capacity to activate protein c due to a point mutation in their thbd gene (tmpro/pro mice) were intranasally infected with b. pseudomallei and sacrificed after 24, 48 or 72 hours for analyses. additionally, survival studies were performed. when compared to wt mice, […]


The Discovery of Dabigatran Etexilate

PMCID: 3569592
PMID: 23408233
DOI: 10.3389/fphar.2013.00012

[…] stability, improved endothelial function, and reduced oxidative stress (preusch et al., ; kadoglou et al., ; lee et al., ). another study in a procoagulant/atherosclerotic mouse model (apoe−/−:tmpro/pro) having elevated coagulation activity due to a loss-of-function mutation in tm demonstrated that dabigatran significantly reduced plaque area and stenosis after a carotid cuff injury […]


Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil Dependent Manner

PMCID: 3567111
PMID: 23409043
DOI: 10.1371/journal.pone.0055784

[…] associated with significant qualitative benefits, including diminished leukocyte infiltration, altered collagen and vascular smooth muscle cell content. genetically-imposed hypercoagulability in tmpro/pro:apoe−/− mice resulted in severe atherosclerosis, plaque vulnerability and spontaneous atherothrombosis. hypercoagulability was associated with a pronounced neutrophilia, neutrophil […]

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TMpro institution(s)
Language Technologies Institute, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA; School of Information Sciences, University of Pittsburgh, Pittsburgh, PA, USA; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

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