Provides a central, user-friendly knowledgebase that integrates data on protein termini, their modifications and information on underlying proteolytic processes extracted from existing valuable resources and make this combined information accessible to a broad audience. TopFIND is designed as non-redundant, protein centric database. Each protein is represented by its genomic encoded polypeptide sequence and further detailed by general annotation such as alternative protein names, protein function and role in disease and by sequence-specific annotation as isoforms, domains and sequence variants. In addition to these commonly assembled protein characteristics TopFIND catalogs detailed information on protein chains, termini, modifications of the terminal amino acid and proteolytic processes.
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada; Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada
TopFIND funding source(s)
The Center for Blood Research [to N.F. and S.Y.]; the Alexander von Humboldt Foundation, the Breast Cancer Society of Canada and the MSFHR [to P.F.L.]; CIHR; Infrastructure Grant from MSFHR; the Canada Foundations for Innovation