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TopHat-Fusion specifications


Unique identifier OMICS_01359
Name TopHat-Fusion
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Computer skills Advanced
Stability Stable
Maintained Yes


No version available


  • person_outline Daehwan Kim <>

Publication for TopHat-Fusion

TopHat-Fusion citations


Genomic alterations of ground glass nodular lung adenocarcinoma

PMCID: 5955945
PMID: 29769567
DOI: 10.1038/s41598-018-25800-2

[…] significantly downregulated genes associated with vasculogenesis compared to the other ggns (fig. ).figure 2figure 3figure 4, a total of five fusion gene loci were detected in four ggns using the tophat fusion tool as follows (table  and supplementary fig. ): mediator complex subunit 13-like (med13l) → tudor domain containing 3 (tdrd3) in ggn3, sterile alpha motif domain containing 12 […]


RNA Seq profiling of circular RNAs in human laryngeal squamous cell carcinomas

PMCID: 5930968
PMID: 29716593
DOI: 10.1186/s12943-018-0833-x
call_split See protocol

[…] rna sample preparation v2 guide, illumina company ltd)., htseq software was used to count the reads numbers mapped to each circrna. rpm (reads per million mapped reads, including tophat mapping and tophat-fusion mapping) [] was employed to calculate the expression level of individual circrna. differential expression between circrnas was assessed by degseq algorithm. we defined the statistical […]


Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation

PMCID: 5927466
PMID: 29668680
DOI: 10.1371/journal.pbio.2005707

[…] 126-nt paired-end reads per individual sample (7–8 flow cell lanes/sample), which were aligned to the hg19 human reference genome (genome reference consortium grch37 from february 2009) [] with tophat-fusion function []. composite rpkm counts within genomic coordinates of 20,304 nonhaplotype hgnc-annotated genes were used to calculate gene expression differences based on log2-transformed […]


Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

PMCID: 5961503
PMID: 29617664
DOI: 10.1016/j.celrep.2018.03.076

[…] involving 224 ddr genes. among these, 464 fgs including 173 ddr genes were derived from tcga cancer samples. to reduce false positives, we used read count information together with fusionscan, tophat-fusion, and prada. following their filtering criteria, we used fusion transcripts having ≥ 2 seed/junction reads for fusionscan and prada analyses, and those with ≥ 100 spanning pairs […]


Genomic profiling of dedifferentiated liposarcoma compared to matched well differentiated liposarcoma reveals higher genomic complexity and a common origin

PMCID: 5880260
PMID: 29610390
DOI: 10.1101/mcs.a002386

[…] in a gene set are harmoniously up- or down-regulated in a sample., to reduce false positives (), we applied an integrative analysis of multiple fusion detection methods. we first applied four tools—tophat-fusion (), mapsplice (), fusionmap (), and prada ()—to detect putative fusions in our nine pairs of frozen wd/dd samples. then, fusions with at least one junction read and at least two […]


Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes

PMCID: 5845222
PMID: 29523209
DOI: 10.1186/s13287-018-0793-5

[…] sequence reads were first multiply mapped against the grch37/hg19 human reference genome using tophat 2.1. unmapped reads were then extracted and mapped onto the relevant reference genome using tophat-fusion. reads that split and aligned on the same chromosome but in noncollinear ordering were extracted as candidate back-spliced junction reads. back-spliced junction reads […]

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TopHat-Fusion institution(s)
Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
TopHat-Fusion funding source(s)
Supported in part by NIH grants R01- LM006845 and R01-HG006102.

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