TopPIC specifications


Unique identifier OMICS_10534
Name TopPIC
Alternative name TOP-Down Mass Spectrometry Based Proteoform Identification and Characterization
Software type Toolkit/Suite
Interface Command line interface
Restrictions to use None
Input data The input of TopPIC consists of a protein database file in the FASTA format and a spectral data file in the msalign format, which is similar to the MGF file format.
Output data TopPIC outputs a tab delimited text file and a collection of html files for identified proteoforms.
Operating system Unix/Linux, Windows
Programming languages C++
Computer skills Advanced
Version 1.0.0
Stability Stable
Maintained Yes


No version available



  • person_outline Xiaowen Liu

Publications for TOP-Down Mass Spectrometry Based Proteoform Identification and Characterization

TopPIC citation


It is time for top down venomics

PMCID: 5648493
PMID: 29075288
DOI: 10.1186/s40409-017-0135-6

[…] rs to enable the identification and characterization of proteins, including coding polymorphisms, PTMs and proteoforms [, ]. Other search engines were also created as MS-Align+, MASH Suite, pTop, and TopPIC, as well as a new score for proteoform specificity, e.g., C-score [–].ProSight PC (Thermo Scientific) is one of the most used tool that performs three distinct types of search: (1) absolute mas […]

TopPIC institution(s)
Department of BioHealth Informatics, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA
TopPIC funding source(s)
The research was partially supported by the National Institute of General Medical Sciences, National Institutes of Health (NIH) through Grant R01GM118470.

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