ToppNet specifications


Unique identifier OMICS_27569
Name ToppNet
Interface Web user interface
Restrictions to use None
Input data Two gene lists (training and test).
Output format HTML
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Bruce Aronow <>
  • person_outline Anil Jegga <>
  • person_outline Eric Bardes <>

Publication for ToppNet

ToppNet in publications

PMCID: 5817168
PMID: 29511491
DOI: 10.22038/ijbms.2018.25175.6236

[…] them in gastric cancer. for training gene set, we used the snps3d server ( to get the list of candidate genes associated with gastric cancer. after that, prioritizing servers: toppnet (, which prioritize and rank candidate genes based on topological features in protein-protein interaction network (), and endeavour […]

PMCID: 5732734
PMID: 29262568
DOI: 10.18632/oncotarget.21874

[…] analysis of the top 100 genes in these two networks suggested the correlation of copd and these genes. the performance of our gene prioritization method was superior to that of toppgene and toppnet for genes from the copd-related metabolic network or the copd-related ppi network after assessing using leave-one-out cross-validation, literature validation and functional enrichment […]

PMCID: 5584748
PMID: 28873096
DOI: 10.1371/journal.pone.0184299

[…] between genes. then a gene prioritization method was applied to the copd-related metabolic network to prioritize copd candidate genes. the gene prioritization method was superior to toppgene and toppnet in both literature validation and functional enrichment analysis. top-ranked genes prioritized from the metabolic perspective with functional information could promote the better […]

PMCID: 5179106
PMID: 28005991
DOI: 10.1371/journal.pone.0168812

[…] drug targets derived from our ‘omics’ mining method, we used the toppgene tool (, which ranks candidate genes based on functional similarity to the training genes, and the toppnet tool (, which ranks candidate genes based on topological features in protein-protein interaction networks and their similarity to the training genes []. […]

PMCID: 5101894
PMID: 27666388
DOI: 10.3892/mmr.2016.5758

[…] in . genes associated with neural system development, apoptosis and transcriptional regulation are listed in according to the functional categories., according to the instructions of toppgene and toppnet, the ‘training gene set’ contained 12 genes associated with toxoplasma, which were collected from the omim and genecards database searches (). prioritization of candidate genes was obtained […]

To access a full list of publications, you will need to upgrade to our premium service.

ToppNet institution(s)
Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
ToppNet funding source(s)
Supported by the State of Ohio Computational Medicine Center (ODD TECH 04-042); National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK) 1U01 DK70219 (Murine Atlas of a Genitourinary Smooth Muscle Development); PHS Grant P30 DK078392 (Cincinnati Digestive Health Center).

ToppNet reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review ToppNet