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TOPSAN specifications


Unique identifier OMICS_03032
Alternative name The Open Protein Structure Annotation Network
Restrictions to use None
Maintained No


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Publication for The Open Protein Structure Annotation Network

TOPSAN citations


Antibiotic binding of STY3178, a yfdX protein from Salmonella Typhi

Sci Rep
PMCID: 4759549
PMID: 26892637
DOI: 10.1038/srep21305

[…] fied protein where the m/z ratio indicates the molecular mass ~23.1 KDa for STY3178. The other peak at 11.5 KDa is assigned for the doubly charged species of the same protein. STY3178 is predicted by Topsan database as a putative membrane protein, however, we find it in the soluble fraction as observed in the SDS-PAGE (, lanes 4 and 8). This observation is in complete agreement with the earlier st […]


Current methods in structural proteomics and its applications in biological sciences

3 Biotech
PMCID: 3376864
DOI: 10.1007/s13205-011-0037-1

[…] he protein structures determined at SP centers are ‘hypothetical proteins’ of unknown function. Insights into the biochemical function of these proteins can be derived by bioinformatics tools such as TOPSAN(The Open Protein Structure Annotation Network), a Web-based platform which facilitates collaborations that have resulted in insightful structure–function analysis for many proteins leading to n […]


1,000 structures and more from the MCSG

BMC Struct Biol
PMCID: 3024214
PMID: 21219649
DOI: 10.1186/1472-6807-11-2

[…] nd the modelling leverage that PSI structures provide. Models are made available through the Protein Model Portal [,]. The JCSG has made a notable effort towards the annotation of PSI structures with The Open Protein Structure Annotation Network (TOPSAN), a wiki-based portal for the dissemination of information for the broad biomedical community [].The increased appearance of structures of protein […]


TOPSAN: use of a collaborative environment for annotating, analyzing and disseminating data on JCSG and PSI structures

PMCID: 2954197
PMID: 20944203
DOI: 10.1107/S1744309110035736

[…] nation. For example, the JCSG has published over 100 peer-reviewed structural papers compared with the more than 1000 structures that it has determined and deposited in the PDB (Fig. 3). In contrast, TOPSAN, as of May 2010, provides entries containing curated analyses for all of the structures determined by the JCSG. Additionally, TOPSAN contains entries with analysis for many proteins in the prod […]


The JCSG high throughput structural biology pipeline

PMCID: 2954196
PMID: 20944202
DOI: 10.1107/S1744309110038212

[…] nski, Jaroszewski, Rychlewski et al., 2007), Quality Control ( and Ligand Search (; Kumar et al., 2010) servers and TOPSAN (; Krishna et al., 2010; Weekes et al., 2010), as well as other tools and resources available on our website ( In particular, the JCSG maintains a crys […]


Structure of BT_3984, a member of the SusD/RagB family of nutrient binding molecules

PMCID: 2954216
PMID: 20944222
DOI: 10.1107/S1744309110032999

[…] teroides polysaccharide-ulitization loci. Models of BT_3984 homologs can be accessed at information about BT_3984 is available from TOPSAN (Krishna et al., 2010; Weekes et al., 2010; […]


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TOPSAN institution(s)
Joint Center for Structural Genomics, Bioinformatics Core, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA

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