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TORTOISE specifications


Unique identifier OMICS_15265
Alternative name Tolerably Obsessive Registration and Tensor Optimization Indolent Software Ensemble
Software type Package/Module
Interface Graphical user interface
Restrictions to use None
Operating system Unix/Linux, Mac OS
Computer skills Medium
Version 2.5.1
Stability Stable
Maintained Yes


No version available



  • person_outline Carlo Pierpaoli

Additional information

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TORTOISE citations


modCHIMERA: a novel murine closed head model of moderate traumatic brain injury

Sci Rep
PMCID: 5955903
PMID: 29769541
DOI: 10.1038/s41598-018-25737-6

[…] commissure. Fractional anisotropy (FA) was calculated using robust estimation of tensors by outlier rejection (RESTORE) in tolerably obsessive registration and tensor optimization indolent software (TORTOISE, Hand-drawn, multislice ROIs were defined by pre-specified anatomical boundaries on FA and b0 images. A voxel-weighted FA mea […]


Ventricular and Periventricular Anomalies in the Aging and Cognitively Impaired Brain

PMCID: 5771258
PMID: 29379433
DOI: 10.3389/fnagi.2017.00445

[…] De-identified DWI scans, as well as T1 and T2-FLAIR images, were uploaded into TORTOISE (Pierpaoli et al., ) for preprocessing. The “diff-prep” command was run with default registration parameters. This consisted of using the T1 and T2 images as structural models to correct for […]


Test retest reliability of high spatial resolution diffusion tensor and diffusion kurtosis imaging

Sci Rep
PMCID: 5593980
PMID: 28894296
DOI: 10.1038/s41598-017-11747-3

[…] signal for that slice on the rest of the DWIs, the entire b-vector series was excluded (Fig. ). The number of b-vector series excluded for each patient is reported in Table . The DIFF_PREP module in TORTOISE ( was used to correct AP and PA data sets separately for subject motion and eddy current distortion as well as susceptibility i […]


Microstructural Alterations and Oligodendrocyte Dysmaturation in White Matter After Cardiopulmonary Bypass in a Juvenile Porcine Model

PMCID: 5586442
PMID: 28862938
DOI: 10.1161/JAHA.117.005997
call_split See protocol

[…] sotropic voxel size of 0.5078 mm per side. A structural multiecho TurboRare T2 image with a TR of 700 and TEs of 34, 124.66, 215.33, and 305.99 ms, rare factor of 8, and 2 averages was also acquired. Tolerably Obsessive Registration and Tensor Optimization Indolent Software Ensemble (TORTOISE) was used to account for echoplanar imaging and eddy current distortion and to process directionally encod […]


In vivo detection of reduced Purkinje cell fibers with diffusion MRI tractography in children with autistic spectrum disorders

Front Hum Neurosci
PMCID: 3938156
PMID: 24592234
DOI: 10.3389/fnhum.2014.00110

[…] ss the degree of head motion (Ling et al., ). The summation of the six motion assessments was used to denote the overall degree of head motion for each child.We utilized a software package called the Tolerably Obsessive Registration and Tensor Optimization Indolent Software Ensemble (TORTOISE version 1.4.0. available from in order to […]


DTIPrep: quality control of diffusion weighted images

Front Neuroinform
PMCID: 3906573
PMID: 24523693
DOI: 10.3389/fninf.2014.00004

[…] n contrast to the highly variable data points in the before-QC graph.We recognize that some of the functionality in DTIPrep has already been published and is available to the community. These include Tortoise (Pierpaoli et al., ), which is a software package for processing dMRI data and consists of two main modules, one for preprocessing and one for analysis, including tensor fitting and ROI analy […]


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TORTOISE institution(s)
NIH Pediatric Neuroimaging Diffusion Tensor MRI Center, Bethesda, MD, USA

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