A resource that analyzes drug-induced gene expression changes at the pathway level. We have collected 2694 pathway concepts and computed numerical response scores of these pathways for 437 drugs and chemicals and 7464 different experimental conditions. ToxDB provides functionalities for exploring these pathway responses by offering tools for visualization and differential analysis allowing for comparisons of different treatment parameters and for linking this data with toxicity annotation and chemical information. ToxDB builds on three components: (i) a comprehensive collection of pathway concepts along with drug treatment microarray data, (ii) a numerical method to compute pathway responses from genome-scale expression data, (iii) a web interface that enables user interaction.
Department of Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Berlin, Germany; Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, Maastricht, Netherlands; Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute, Maastricht University, Maastricht, Netherlands
ToxDB funding source(s)
This work was supported by the HeCaToS project as part of the EU Seventh Framework Programme (602156) and by the Max Planck Society.