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Toxicogenomics focuses on assessing the safety of compounds using gene expression profiles. Gene expression signatures from large toxicogenomics databases are expected to perform better than small databases in identifying biomarkers for the prediction and evaluation of drug safety based on a compound's toxicological mechanisms in animal target organs.
(Igarashi et al., 2015) Open TG-GATEs: a large-scale toxicogenomics database. Nucleic Acids Res.