A toxicogenomics database that stores gene expression profiles and traditional toxicological data derived from in vivo (rat) and in vitro (primary rat hepatocytes, primary human hepatocytes) exposure to 170 compounds at multiple dosages and time points.
A resource that analyzes drug-induced gene expression changes at the pathway level. We have collected 2694 pathway concepts and computed numerical response scores of these pathways for 437 drugs and chemicals and 7464 different experimental conditions. ToxDB provides functionalities for exploring these pathway responses by offering tools for visualization and differential analysis allowing for comparisons of different treatment parameters and for linking this data with toxicity annotation and chemical information. ToxDB builds on three components: (i) a comprehensive collection of pathway concepts along with drug treatment microarray data, (ii) a numerical method to compute pathway responses from genome-scale expression data, (iii) a web interface that enables user interaction.
Covers toxicogenomic signatures. TOXsIgN aims to archive heterogeneous data and allows users to upload lists of overexpressed/underexpressed genes from different omics experiments. It can provide data usable for cross-species and cross-technology comparisons. This database contains over 750 projects for about 900 transcriptomic studies of more than 450 compounds performed in humans, rats, mice, or drosophila.
Gathers literature-based, manually curated associations between chemicals, gene products, phenotypes, diseases, and environmental exposures. CTD is a public resource aiming to advance the understanding about chemical exposures and human health. The database provides more than 38 million toxicogenomic relationships, as well as analysis tools. Users can explore novel connections and generate testable hypotheses about the molecular mechanisms of chemical influenced health outcomes.
A robust and sustainable infrastructure storing toxicogenomics data. A central data warehouse is connected to a portal with links to chemical information and molecular and phenotype data. diXa is publicly available through a user-friendly web interface. New data can be readily deposited into diXa using guidelines and templates available online. Analysis descriptions and tools for interrogating the data are available via the diXa portal.
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