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TP-Search specifications

Information


Unique identifier OMICS_13342
Name TP-Search
Alternative name Transporter Protein Search
Restrictions to use None
Community driven No
Data access File download, Browse
User data submission Not allowed
Maintained Yes

Publication for Transporter Protein Search

TP-Search citations

 (3)
library_books

How Open Data Shapes In Silico Transporter Modeling

2017
PMCID: 5553104
PMID: 28272367
DOI: 10.3390/molecules22030422

[…] silico transporter models is no longer a major limitation for many transport proteins. Open data sources for small compound transporter bioactivity data include specialized transporter databases like TP search [], Metrabase (Metabolism and transport database) [] and UCSF-FDA TransPortal [], as well as broad compound collections like ChEMBL [] (e.g., 9.8% of compounds in ChEMBL_22 report measuremen […]

library_books

Comparability of Mixed IC50 Data – A Statistical Analysis

2013
PLoS One
PMCID: 3628986
PMID: 23613770
DOI: 10.1371/journal.pone.0061007

[…] tion can be compared as The problem is that assay details are not reported in public bioactivity databases. Recently, Zdrazil et al. analyzed human P-glycoprotein bioassay data from the ChEMBL and TP-search databases. They explore the ability of these data, determined in different assays, to be combined with each other. Their study indicates that for inhibitors of human P-glycoprotein this is […]

library_books

Fingerprint based in silico models for the prediction of P glycoprotein substrates and inhibitors

2012
PMCID: 3445814
PMID: 22595422
DOI: 10.1016/j.bmc.2012.03.045

[…] erties.The models developed were further validated by applying them to known P-gp substrates/non-substrates extracted from publicly available data sources. For this, we considered three data sources: TP search (www.tp-search.jp), Drug Bank (www.drugbank.ca) and compounds taken from literature. Duplicates and overlapping compounds were removed from the respective data sets. Unfortunately, for TP se […]

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TP-Search institution(s)
Wyeth KK, Tokyo, Japan; Advanced Research Institute for Science and Engineering, Waseda University, Tokyo, Japan; Nihon Visual Science, Inc, Tokyo, Japan; Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan
TP-Search funding source(s)
This study was supported by Grant-in-Aid for Scientific Research (Publication of Scientific Research Results) from Japan Society for the Promotion of Science (2005-2006).

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