Performs a comprehensive analysis of the combinatorial nature of gene regulation by detecting rules that identify a set of miRNAs associated with genes. The algorithm of Tran et al. is a computational method for finding miRNA regulatory modules (MRMs) from their predicted target genes and expression datasets (mRNA expression profiles and miRNA expression profiles). The method extracts IFTHEN rules of miRNA combinations shared by target genes with a common expression profile.
School of Knowledge Science, Japan Advanced Institute of Science and Technology, Nomi, Japan; Kanazawa University, Kakuma, Japan
TranEtAl2008 funding source(s)
Supported by the Institute for Bioinformatics Research and Development of the Japan Science and Technology Agency, by COE project JCP KS1 of the Japan Advanced Institute of Science and Technology, and by Japanese government scholarship (Monbukagakusho) to study in Japan.