A repository of sequence specificity models and condition-specific regulatory activities for a large number of DNA- and RNA-binding proteins in Saccharomyces cerevisiae. The web interface allows the user to dynamically interact with published microarray data and easily discern otherwise hidden regulatory patterns. TransfactomeDB has the advantages of (i) having a uniform, biophysically motivated representation of sequence specificities in the form of PSAMs; (ii) providing condition-specific regulatory information for each PSAM; and (iii) predicting single-nucleotide TF-binding affinity profiles for arbitrary DNA and RNA sequences.
Department of Biological Sciences, Columbia University, New York, NY, USA; Integrated Program in Cellular, Molecular and Biophysical Studies and Center for Computational Biology and Bioinformatics, Columbia University, New York, NY, USA
TransfactomeDB funding source(s)
This work was supported by National Institutes of Health (NIH) training grant T32GM008798 and grants R01HG003008, U54CA121852.