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Translated open reading frame detection software tools | Ribosome profiling data analysis

Ribosome profiling via high-throughput sequencing (ribo-seq) is a promising new technique for characterizing the occupancy of ribosomes on messenger RNA (mRNA) at base-pair resolution. The ribosome is responsible for translating mRNA into proteins, so information about its occupancy offers a detailed view of ribosome density and position which could be used to discover new translated open reading frames (ORFs), among other things.

Source text:
(Malone et al., 2017) Bayesian prediction of RNA translation from ribosome profiling. Nucleic Acids Res.

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