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TREEspot specifications

Information


Unique identifier OMICS_18169
Name TREEspot
Software type Package/Module
Interface Graphical user interface
Restrictions to use License purchase required
Computer skills Medium
Version 5.0
Stability Stable
Maintained Yes

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  • person_outline TREEspot Team <>

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TREEspot in publications

 (10)
PMCID: 5859083
PMID: 29593536
DOI: 10.3389/fphar.2018.00205

[…] kinase dendrogram, red circles indicated the main hits (<5% of control), weak or no hits were labeled with small red circles (10–35% of control) and smaller green circles (>35% of control). treespot is a proprietary data visualization software developed by kinomescan that shows the protein kinase binding affinity., to evaluate the antitumor activity of mpt0b451, 4-week-old male nude […]

PMCID: 5841367
PMID: 29531836
DOI: 10.1038/s41420-018-0042-9

[…] measured the interactions of mdivi-1 (10 µm in 0.1% dmso) with 468 kinases covering more than 80% of the human kinome and disease-relevant mutant variants. kinase dendrogram was generated using treespot software (http://www.kinomescan.com). the readout from kinomescan assay is ‘percent of control’, where the control is 0.1% dmso and 100% indicates no inhibition of the kinase by mdivi-1 […]

PMCID: 5851644
PMID: 29466002
DOI: 10.1021/acs.jmedchem.7b01605

[…] μm, in duplicate) against 369 wild-type kinases. enzymatic inhibition was compared to dmso (= 0% inhibition) and averaged results plotted in a kinome phylogenetic tree with a 65% cutoff value using treespot from discoverx (; values listed in supporting information, table 1). the study gave a s-score of 0.22 and, although not as potent as flt3, most hits (>65% inhibition) belonged […]

PMCID: 5819301
PMID: 29463296
DOI: 10.1186/s13395-018-0150-5

[…] of the control condition in each case (dmso treated cells). we analyzed myogenin, myod, and cyclind1 rt-pcr expected product using a 2% agarose gel., figure a image was generated with the discoverx treespot™ compound profile visualization software v4.0 using quantitative affinity data derived from the discoverx kinomescan® platform […]

PMCID: 5508574
PMID: 26928769
DOI: 10.1038/nbt.3460

[…] binding was performed by discoverx (fremont, ca) using their kinomescan method, using the scanedge profile (97 kinases) plus the inclusion of aurkc (total 98 kinases). images were generated using treespot™ software tool and reprinted with permission from kinomescan, a division of discoverx corporation., enzyme kinetic experiments were performed at ph 7.0 in 8 mm mops buffer with 0.2 mm edta […]


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