Trinculo specifications


Unique identifier OMICS_11474
Name Trinculo
Software type Package/Module
Interface Command line interface
Restrictions to use None
Input data Trinculo uses a PLINK-style format to enter commands and specify input and output files, and reads data in standard formats, including binary PLINK and dosage formats for genotypes and standard text formats for phenotypes and covariates.
Operating system Unix/Linux, Mac OS
Programming languages C
Computer skills Advanced
Stability Stable
Maintained Yes




No version available


  • person_outline Luke Jostins

Publication for Trinculo

Trinculo citations


Statistical methods to detect pleiotropy in human complex traits

Open Biol
PMCID: 5717338
PMID: 29093210
DOI: 10.1098/rsob.170125

[…] geneous effects. While not technically multivariate, this type of analysis requires individual-level data. Bayesian and frequentist multinomial regression has been implemented in the software package Trinculo []. The Bayesian approach was recently used to determine which of a group of six immune disorders was associated with previously identified risk loci []. […]


Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease specific patterns at shared loci

Nat Genet
PMCID: 4848113
PMID: 26974007
DOI: 10.1038/ng.3528

[…] it naturally handles the different uncertainties on the effect sizes for each disease due to their different sample sizes and powers. The methods we describe below are implemented in the open source Trinculo software package.The Bayesian multinomial logistic regression software calculates a marginal likelihood for each model, integrating out uncertainty in the effect size, as Pr(D∣M)=∫βPr(D∣β)Pr( […]

Trinculo institution(s)
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; Christ Church, University of Oxford, Oxford, UK
Trinculo funding source(s)
The work was funded by the Wellcome Trust [098759/Z/12/Z and 100956/Z/13/Z], and by Christ Church, Oxford.

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