Allows users to predict chemically modified nucleosides in tRNA sequences. tRNAmodpred can provide valuable initial predictions that could be a starting point for experimental analyses. Its predictions are based on detection of homology to known RNA modification enzymes. The quality of these predictions depends on the data about modified tRNA sequences and RNA modification enzymes. The method of this tool is also applicable to other conserved RNA molecules (such as rRNA).
Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology, Warsaw, Poland; Department of Microbiology and Cell Science, University Florida, Gainesville, FL, USA; Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznan, Poland
tRNAmodpred funding source(s)
Supported by the Foundation for Polish Science (FNP, grant TEAM/2009–4/2) and subsequently by the Polish National Science Center (NCN, grant 2012/04/A/ NZ2/00455); the European Commission (7FP grant Fishmed, GA No. 316125 at IIMCB); the European Union (European Social Fund – stipend for Mazovian PhD students, Human Capital Operational Program 2007–2013); the Polish National Science Centre (NCN) (grant 2011/03/D/NZ8/03011) and by a fellowship for outstanding young scientists from the Polish Ministry of Science and Higher Education; the National Institutes of Health (grant number R01 GM70641).