Provides detailed annotations for each tumor suppressor genes (TSGs), such as cancer mutations, gene expressions, methylation sites, transcription factor regulations and protein-protein interactions. The TSGene version 2.0, which has substantial updates of contents (e.g. up-to-date literature and pan-cancer genomic data collection and curation), data types (noncoding RNAs and protein-coding genes) and content accessibility. Specifically, the current TSGene 2.0 contains 1217 human TSGs (1018 protein-coding and 199 non-coding genes) curated from over 9000 articles. Additionally, TSGene 2.0 provides thousands of expression and mutation patterns derived from pan-cancer data of The Cancer Genome Atlas.
Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA; Center for Quantitative Sciences, Vanderbilt University, Nashville, TN, USA
TSGene funding source(s)
National Institutes of Health (NIH) [R01LM011177, P50CA095103, P50CA098131 and P30CA068485 in part] and Ingram Professorship Funds