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TSGene specifications

Information


Unique identifier OMICS_04170
Name TSGene
Restrictions to use None
Version 2.0
Maintained No

Taxon


  • Primates
    • Homo sapiens

Publications for TSGene

TSGene citations

 (8)
library_books

Recently Evolved Tumor Suppressor Transcript TP73 AS1 Functions as Sponge of Human Specific miR 941

2018
Mol Biol Evol
PMCID: 5913670
PMID: 29474580
DOI: 10.1093/molbev/msy022

[…] ownloaded from GSE66729. We used the processed gene expression matrix based on sense strand reads for our analysis. The TSG list was downloaded from TSG database 2.0 (http://bioinfo.mc.vanderbilt.edu/TSGene/). […]

library_books

Identification of key genes associated with bladder cancer using gene expression profiles

2017
PMCID: 5766060
PMID: 29375713
DOI: 10.3892/ol.2017.7310

[…] ding-sites#resources) () was performed on DEGs to determine whether the genes were transcription factors. The DEGs were also submitted to the Tumor Suppressor Gene database (bioinfo.mc.vanderbilt.edu/TSGene) () and the Tumor-Associated Gene database (blog.synopse.info/tag/Database) () to obtain all known proto-oncogenes and tumor suppressor genes. […]

library_books

KRAS driven miR 29b expression is required for tumor suppressor gene silencing

2017
Oncotarget
PMCID: 5650376
PMID: 29088821
DOI: 10.18632/oncotarget.20364

[…] imitive subtypes (Figure ). Focusing on TSGs, we analyzed expression of a set of 534 mRNAs depressed in lung SCC compared to normal lung in the Tumor Suppressor Gene database (https://bioinfo.uth.edu/TSGene/). As shown in , we identified 44 genes that are significantly down-regulated in the basal/secretory subtype. For further validation in HBEC3 and H1299 cells, we selected 13 genes with more tha […]

library_books

Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer

2017
Biomed Res Int
PMCID: 5394352
PMID: 28473981
DOI: 10.1155/2017/2769140

[…] ed to the enrichment of 17P13 gene set and 12 genes contributed to the enrichment of 17P12 gene set. A total of 1217 known tumor suppressor genes was searched from the tumor suppressor gene database (TSGene 2.0) [, ]. Intersection was performed among the 1217 genes and previously mentioned 89 genes, and 8 tumor suppressor genes (HIC1, VPS53, RPA1, ALOX15B, TP53, PFN1, MYBBP1A, and GABARAP) were ob […]

library_books

Identification of an atypical etiological head and neck squamous carcinoma subtype featuring the CpG island methylator phenotype

2017
PMCID: 5360591
PMID: 28314692
DOI: 10.1016/j.ebiom.2017.02.025

[…] t CIMP does not selectively silence any particular class of genes. However, genes that were downregulated and/or hypermethylated in the CIMP-Atypical subtype included tumor suppressor genes listed by TSgene () and genes that are causally implicated in cancer, listed within COSMIC cancer Gene Census () (), indicating that CIMP alters cancer gene expression pathways. […]

library_books

iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing driver genes in personal cancer genomes

2016
Genome Med
PMCID: 5180414
PMID: 28007024
DOI: 10.1186/s13073-016-0390-0

[…] ning set, we required that all TN observations not be present in the KEGG Cancer Pathway [], or be defined as Oncogenes by the UniProt database [], or be defined by the Cancer Suppressor Genes in the TSGene database (https://bioinfo.uth.edu//TSGene1.0/index.html) [], or have a maximum radial SVM score greater than 0.93. Next, for each observation, we harvested their four feature scores as follows. […]

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TSGene institution(s)
Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA; Center for Quantitative Sciences, Vanderbilt University, Nashville, TN, USA
TSGene funding source(s)
National Institutes of Health (NIH) [R01LM011177, P50CA095103, P50CA098131 and P30CA068485 in part] and Ingram Professorship Funds

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