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TTD specifications


Unique identifier OMICS_04941
Name TTD
Alternative name Therapeutic Target Database
Restrictions to use None
Community driven No
Data access File download, Browse
User data submission Not allowed
Version 6.1.01
Maintained Yes


  • person_outline Feng Zhu
  • person_outline Yu Zong Chen

Publications for Therapeutic Target Database

TTD citations


Systems pharmacology approach reveals the antiinflammatory effects of Ampelopsis grossedentata on dextran sodium sulfate induced colitis

PMCID: 5889820
PMID: 29632421
DOI: 10.3748/wjg.v24.i13.1398

[…] identification of candidate targets for AMP against UC: To better understand the mechanisms of AMP in the treatment of UC, 123 candidate targets of UC were obtained from Genetic Association database, Therapeutic Target database and Online Mendelian Inheritance in Man database (Supplementary Table 6). As PPI maps represented physical interactions on a molecular level[], a putative-target network (4 […]


Docking based inverse virtual screening: methods, applications, and challenges

Biophysics Rep
PMCID: 5860130
PMID: 29577065
DOI: 10.1007/s41048-017-0045-8

[…] base, but also complicate the subsequent analysis of the screening results. To address this issue, several databases that focus on specific topics have been constructed, and are introduced as follows.Therapeutic target database (TTD) (Chen et al. ) focuses on known and potential therapeutic targets, which are proteins and nucleic acids collected from literature. Important information, such as targ […]


A census of P. longum’s phytochemicals and their network pharmacological evaluation for identifying novel drug like molecules against various diseases, with a special focus on neurological disorders

PLoS One
PMCID: 5761900
PMID: 29320554
DOI: 10.1371/journal.pone.0191006

[…] ins) [], BindingDB [], SwissTargetPrediction [] and PCIDB.The protein-chemical interaction reported in STITCH comes from the manually curated datasets including DrugBank [] GLIDA [], Matador [], TTD (Therapeutic target database) [] etc. In order to provide a full picture of the available data, STITCH also integrates information from several metabolic pathway databases and experimentally validated […]


Exploring the pathogenesis of canine epilepsy using a systems genetics method and implications for anti epilepsy drug discovery

PMCID: 5862570
PMID: 29568349
DOI: 10.18632/oncotarget.23719

[…] scovery, we counted the enrichment of the drugs in these subnetworks. We collected and sorted 5,452 active drugs corresponding to 2,440 targets in three databases: DrugBank (, Therapeutic Target Database, (TTD,, and ClinicalTrials ( Among them, there were 79 drugs for the treatment of epilepsy, generating […]


Total Coumarins from Hydrangea paniculata Show Renal Protective Effects in Lipopolysaccharide Induced Acute Kidney Injury via Anti inflammatory and Antioxidant Activities

Front Pharmacol
PMCID: 5735979
PMID: 29311915
DOI: 10.3389/fphar.2017.00872

[…] rom the “Pubmed compound database,” and were placed into the Similarity ensemble approach (SEA) database ( for simulating molecular docking. The predicted targets were input to Therapeutic Target Database (TTD), PharmGKB, and Drugbank databases to identify their roles in inflammation and renal disease. […]


Predicted molecular targets and pathways for germacrone, curdione, and furanodiene in the treatment of breast cancer using a bioinformatics approach

Sci Rep
PMCID: 5686110
PMID: 29138518
DOI: 10.1038/s41598-017-15812-9

[…] pathway, related disease, and gene ontology results. In the disease module, breast cancer is associated with 7 target genes/proteins (CYP19A1, ESR1, ESR2, HSP90AA1, PGR, SRC, VDR) as analyzed by TTD (Therapeutic Target Database, Supplementary Table ) and 5 target genes/proteins (ATM, ESR1, PHB, PIK3CA, TP53) as analyzed by OMIM (Online Mendelian Inheritance in Man, Supplementary Table ) that may b […]


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TTD institution(s)
Bioinformatics and Drug Design Group, Department of Pharmacy and Center for Computational Science and Engineering, National University of Singapore, Singapore, Singapore; Innovative Drug Research and Bioinformatics Group, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China; Innovative Drug Research and Bioinformatics Group, School of Pharmaceutical Sciences, Chongqing University, Chongqing, China; Zhejiang Key Laboratory of Gastro-intestinal Pathophysiology, Zhejiang Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Hangzhou, China
TTD funding source(s)
Supported by Singapore Academic Research Fund [R-148–000-208– 112, R-148–000-230–114, R-148–000-239–114]; Precision Medicine Project of the National Key Research and Development Plan of China [2016YFC0902200]; Innovation Project on Industrial Generic Key Technologies of Chongqing [cstc2015zdcy-ztzx120003].

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