Tumor heterogeneity deconvolution software tools| ChIP sequencing data analysis
Sample heterogeneity can have a considerable effect on transcription factor binding site detection. While manual separation techniques can be used to isolate a cell type of interest from heterogeneous samples, such techniques are challenging and can change intra-cellular interactions, including protein-DNA binding. Computational deconvolution methods have emerged as an alternative strategy to study heterogeneous samples and numerous methods have been proposed to analyze gene expression.
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