bookmark MixChIP Obsolete A probabilistic method to identify cell type specific TF binding sites from heterogeneous chromatin immunoprecipitation sequencing (ChIP-seq) data. First, the cell type proportions in each ChIP sample and cell type specific signal are estimated. Second, the estimated proportions are used to deconvolve the signal in the input control samples using three different regions around the candidate binding site regions. MixChIP simultaneously estimates the binding strength in different cell types as well as the proportions of different cell types in each sample when only partial prior information about cell type composition is available. MixChIP is the first computational deconvolution method designed for ChIP-sequencing data and it can be a valuable tool in analyzing heterogeneous ChIP-seq samples originating, for instance, from tumor biopsy samples.