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Deconvolutes of DNA methylation array data into source contributions from distinct cell types. methylSpectrum is a method for inferring changes in the distribution of white blood cells between different subpopulations using DNA methylation signatures in combination with an appropriate external validation set. methylSpectrum employs the concept of differentially methylated DNA regions (DMR) as markers of immune cell identity using a high-density methylation platform. With these considerations, a set of analytical tools for estimating the proportions of immune cells in unfractionated whole blood is proposed in methylSpectrum tool.
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